Cardiovascular disease (CVD) is the leading cause of death in Western societies and accounts
for up to a third of all deaths worldwide. In comparison to the Northern European or other …

Anthracyclines are among the most effective anticancer drugs ever developed. Unfortunately,
their clinical use is severely limited by the development of a progressive dose-dependent …

Cancer is one of the major public health problems worldwide representing the leading
cause of morbidity and mortality in industrialized countries. To reduce cancer morbidity and …

Oxidative stress is postulated to be increased in patients with IDDM. Accumulating evidence
suggests that oxidative cell injury caused by free radicals contributes to the development of …

The anthracycline doxorubicin (DOX) is an exceptionally good antineoplastic agent, but its
use is limited by formation of metabolites which induce acute and chronic cardiac toxicities. …

Anticancer therapy with doxorubicin (DOX) is limited by severe cardiotoxicity, presumably
reflecting the intramyocardial formation of drug metabolites that alter cell constituents and …

Mild oxidative stress, as elicited by ascorbate, oxygen, and trace metals, affects the binding
properties of human serum albumin via purely conformational changes. In fact, no gross …

Concentrations of glutathione, uric acid and total antioxidant activity, expressed as Trolox (a
water-soluble vitamin E analogue) equivalent, were measured in the saliva of healthy non-…

Substantial evidence supports the hypothesis that oxygen free radicals are involved in various
neurodegenerative disorders. To assess the presence of oxidative stress in Alzheimer's …

Idebenone [2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone] is a synthetic
analogue of coenzyme Q that is currently employed in the treatment of vascular and …