Background Isolated systolic hypertension occurs in about 15% of people aged 60 years or
older. In 1989, the European Working Party on High Blood Pressure in the Elderly …

The development of agents capable of pro-ducing selective blockade of beta-adrenoceptors
has proved to be one of the most fruitful, informative, and therapeutically exciting …

The left lung from a dog was removed, ventilated with negative pressure, and perfused with
venous blood. Pulmonary arterial, venous, and alveolar pressures could be varied over a …

Inhaled radioactive CO 2 is rapidly taken up by pulmonary blood. By external counting over
the chest during breath holding, the clearance rate of radioactive CO 2 xs from the counting …

Many drug targets are intracellular. To access them, a drug molecule must pass through the
cell membrane, a process often facilitated or impeded by transporters. Once in the cytoplasm…

Eight men volunteers each smoked a single cirgarette containing 14C-nicotine and gave
arterial blood samples during and for 50 minutes after smoking. The maximum concentration of …

We report the development of a 3D OrbiSIMS instrument for label-free biomedical imaging. It
combines the high spatial resolution of secondary ion mass spectrometry (SIMS; under 200 …

Five healthy normotensive volunteers (mean ± SEM age 29.6 ± 4.6 years) were infused with
l-noradrenaline for a 15 min period every 3 hours for 24 hours from 0900. The …

26 patients with systemic lupus erythematosus (SLE) induced by treatment with the
antihypertensive drug hydralazine were investigated to determine if predisposition to the toxic effect …

The IUPHAR database (IUPHAR-DB) integrates peer-reviewed pharmacological, chemical,
genetic, functional and anatomical information on the 354 nonsensory G protein-coupled …