Nucleoside analogs are structurally similar antimetabolites that have a broad range of action
and are clinically active in both solid tumors and hematological malignancies. Many of …

… NAMPT is the rate-limiting enzyme in this pathway and converts NAM to nicotinamide
mononucleotide (NMN) by catalyzing the reversible addition of a ribose group from 5-phospho-α-d-…

Nucleoside analogs are structurally, metabolically, and pharmacodynamically related agents
that nevertheless have diverse biological actions and therapeutic consequences. This …

Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are key regulators of the apoptotic
process. This family comprises proapoptotic and prosurvival proteins, and shifting the balance …

Barley (Hordeum vulgare L.) is among the world's earliest domesticated and most important
crop plants. It is diploid with a large haploid genome of 5.1 gigabases (Gb). Here we present …

Cereal grasses of the Triticeae tribe have been the major food source in temperate regions
since the dawn of agriculture. Their large genomes are characterized by a high content of …

We discuss the video recommendation system in use at YouTube, the world's most popular
online video community. The system recommends personalized sets of videos to users …

Herceptin (trastuzumab) is the backbone of HER2-directed breast cancer therapy and benefits
patients in both the adjuvant and metastatic settings. Here, we describe a mechanism of …

The anti-apoptotic protein MCL-1 is a key regulator of cancer cell survival and a known
resistance factor for small-molecule BCL-2 family inhibitors such as ABT-263 (navitoclax), making …

The BCL-2/BCL-X L /BCL-W inhibitor ABT-263 (navitoclax) has shown promising clinical activity
in lymphoid malignancies such as chronic lymphocytic leukemia. However, its efficacy in …