Click chemistry has been employed for the assembly of novel and efficient triazole-based
multidentate chelating systems while simultaneously attaching them to molecules of biological …

Bifunctional μ- and δ-opioid receptor (OR) ligands are potential therapeutic alternatives, with
diminished side effects, to alkaloid opiate analgesics. We solved the structure of human δ-…

… Dirk Tourwé (inset) obtained his PhD degree at the VUB in 1974. He became director of the
… Notably, they all contain the L,D,L,D stereochemical pattern. SAR studies proved that this L,D…

A new peptide labeling method that uses the Organometallic aquaion [99rnTc (H2O) 3 (CO)
3]+ has been developed. Methods: A selection of amino acids was labeled at different …

… The new analogues showed a shift in hydrophilicity from a Log D = 0.9 to Log D values …
with Log D values between +1 and −1 showed the highest binding affinities with K d values …

… In summary, when the four C-terminal amino acids of 62 are constrained by the d-Tic-Oic
dipeptide motif which produces 63, excellent affinity and potency toward the B 2 receptors are …

… Neoplastic pancreatic ducts (arrows) are strongly labeled in C but not in D. (E and F)
Autoradiograms show absence of nonspecific binding in presence of 10 −6 mol/L NT. …

The overexpression of neuropeptide receptors observed in many cancers provides an attractive
target for tumor imaging and therapy. Bombesin is a peptide exhibiting a high affinity for …

… xenograft (A), liver (B), kidneys (C), and human prostate carcinoma PC-3 xenograft (D).
Tumors were induced by subcutaneous injection of 8 × 10 6 cells of each type 10 d before assay. …

… The receptor affinity of the new technetium 99m ([ 99m Tc])-labeled BBS analogues was
similar to the unmodified compound with K d <1 nM. Uptake in the pancreas and in PC-3 tumor …