[HTML][HTML] Implication of inflammatory signaling pathways in obesity-induced insulin resistance

JF Tanti, F Ceppo, J Jager, F Berthou - Frontiers in endocrinology, 2013 - frontiersin.org
Obesity is characterized by the development of a low-grade chronic inflammatory state in
different metabolic tissues including adipose tissue and liver. This inflammation develops in …

Metabolism of eicosapentaenoic and docosahexaenoic acids by recombinant human cytochromes P450

…, D Lucas, L Corcos, JP Salaün, F Berthou… - Archives of biochemistry …, 2008 - Elsevier
Epoxidation and hydroxylation of arachidonic acid (AA) are both catalyzed by cytochromes
P450s (CYPs). The oxidized metabolites are known to be involved in the regulation of …

Involvement of Cytochrome P450 3A4 Enzyme in the N-Demethylation of Methadone in Human Liver Microsomes

C Iribarne, F Berthou, S Baird, Y Dréano… - Chemical research in …, 1996 - ACS Publications
Methadone has become one of the most widely used drugs for opiate dependency treatment.
This drug is extensively metabolized by the cytochrome P450 hepatic enzyme family in man…

Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components

B Piver, F Berthou, Y Dreano, D Lucas - Toxicology letters, 2001 - Elsevier
… Xtra Old Cognac® was a gift from the Bureau National Interprofessionnel du cognac (Cognac,
F). … Resorufin and ethoxyresorufin were purchased from Interchim (Montluçon, F). …

Involvement of cytochrome P450 3A4 in N-dealkylation of buprenorphine in human liver microsomes

C Iribarne, D Picart, Y Dréano, JP Bail, F Berthou - Life sciences, 1997 - Elsevier
… The metabolic rates were 3.46 f. 0.43 nmol/(min x mg of protein). This metabolic pathway …
P450 3A content of liver microsomal samples (F = 0.87). Buprenorphine metabolism was 62-71…

Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes

…, X Vitrac, JM Merillon, Y Dreano, F Berthou… - Biochemical …, 2004 - Elsevier
This study was aimed at identifying the isoform(s) of human liver cytochrome P450 (CYP)
involved in the hepatic biotransformation of trans-resveratrol (trans-3,5,4′-trihydroxystilbene). …

CYP1A1, CYP2E1 and GSTM1 genetic polymorphisms. The effect of single and combined genotypes on lung cancer susceptibility in Chilean people

L Quinones, D Lucas, J Godoy, D Cáceres, F Berthou… - Cancer letters, 2001 - Elsevier
CYP1A1, CYP2E1 and GSTM1 polymorphisms were evaluated in Chilean healthy controls
and lung cancer patients. In the Chilean healthy group, frequencies of CYP1A1 variant …

Differential inhibition of human cytochrome P450 enzymes by ε-viniferin, the dimer of resveratrol: comparison with resveratrol and polyphenols from alcoholized …

B Piver, F Berthou, Y Dreano, D Lucas - Life sciences, 2003 - Elsevier
… Benzoxyresorufin, resorufin and ethoxyresorufin were purchased from Interchim (Montluçon,
F). C-lauric acid was purchased from Amersham (Piscataway, USA). Red wine (Merlot) and …

[HTML][HTML] Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism1

…, Y Dréano, E Plée-Gautier, JP Salaün, F Berthou… - Journal of lipid …, 2008 - ASBMB
Human CYP450 ω-hydroxylases of the CYP4 family are known to convert arachidonic acid (AA)
to its metabolite 20-hydroxyeicosatetraenoic acid (20-HETE). This study deals with …

Cytochrome P450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects

D Lucas, C Ménez, C Girre, F Berthou… - Pharmacogenetics …, 1995 - journals.lww.com
Susceptibility to cancer or ethanol-related liver diseases may be associated with a large
variability in cytochrome P450 2E1 activity. This variability may be of genetic origin or reflect …