Cytochrome P-450 and its role in drug metabolism

JR Gillette, DC Davis, HA Sasame - Annual Review of …, 1972 - annualreviews.org
58 GILLETTE, DAVIS & SASAME monooxygenases according to the nomenclature of Hayaishi
(6). But whether the reactions are catalyzed by a single enzyme or a family of difн ferent …

Oxidation of α-methyldopa and other catechols by cytochrome P-450-generated superoxide anion: possible mechanism of methyldopa hepatitis

E Dybing, SD Nelson, JR Mitchell, HA Sasame… - Molecular …, 1976 - ASPET
Renewed interest in the hepatic injury produced by α-methyldopa has been stimulated by
recent reports that the antihypertensive drug may initiate chronic active liver disease, …

Cytochrome P-450 and NADPH cytochrome c reductase in rat brain: formation of catechols and reactive catechol metabolites

HA Sasame, MM Ames, SD Nelson - Biochemical and biophysical research …, 1977 - Elsevier
Microsomes isolated from whole rat brain were found to contain cytochreme P-450 (0.025 to
0.051 nmoles/mg) and NADPH cytochrome c reductase activity (26.0 to 55.0 nmoles/mg/min)…

High concentrations of glutathione in glandular stomach: possible implications for carcinogenesis

SC Body, HA Sasame, MR Body - Science, 1979 - science.org
Sasame and Boyd (7) previously have reported that concentrations of hepatic GSH were
elevated by prior treatments with cobaltous chloride or salts of several other divalent metals. …

[PDF][PDF] Metabolic activation of furosemide to a chemically reactive, hepatotoxic metabolite.

JR Mitchell, WL Nelson, WZ Potter, HA Sasame… - … of Pharmacology and …, 1976 - Citeseer
ABSTRACT MITCHELL, JR, WL NELSON, WZ POTFER, HA SASAME AND DJ JoLLow:
Metabolic activation of furosemide to a chemically reactive. hepatotoxic metabilite. J …

Gastric glutathione depletion and acute ulcerogenesis by diethylmaleate given subcutaneously to rats

SC Boyd, HA Sasame, MR Boyd - Life sciences, 1981 - Elsevier
The subcutaneous administration of diethylmaleate (DEM), a drug known previously to deplete
liver glutathione (GSH), was shown in rats to cause a severe dose-dependent, rapid and …

[PDF][PDF] Mechanism of p-nitrobenzoate reduction in liver: the possible role of cytochrome P-450 in liver microsomes

JR GILLETTE, JJ KAMM, HA SASAME - Molecular Pharmacology, 1968 - Citeseer
The following evidence suggests that the reduction of p-nitrobenzoate to p-aminobenzoate
by liver microsomes is mediated by cytochrome P. 450:(a) carbon monoxide blocks …

Soybean amino acids, amino acids in soybean hulls and oil meal fractions

JJ Rackis, RL Anderson, HA Sasame… - Journal of agricultural …, 1961 - ACS Publications
Amino acids were determined by ion exchange chromatography on soybean hulls, de-hulled
soybean meal, isolated soybean protein, and the residue; on whey proteins obtained by …

Studies on the destruction of liver microsomal cytochrome P-450 by carbon tetrachloride administration

HA Sasame, JA Castro, JR Gillette - Biochemical Pharmacology, 1968 - Elsevier
Carbon tetrachloride impairs the oxidative enzymes in liver microsomes by decreasing the
amount of cytochrome P-450. The destruction is probably not mediated by an increase in lipid …

3H-Benzene metabolism in rabbit bone marrow

LS Andrews, HA Sasame, JR Gillette - Life sciences, 1979 - Elsevier
An assay for benzene metabolism using 3 H-benzene and high pressure liquid chromatography
was developed. H-Benzene metabolism (2 pmoles benzene equivalents/mg protein/min…