… Subsequently, Sasame showed that the effect of low concentrations of oxygen on the slower
phases of cytochrome P-450 reduction was due to an unusually slow reduction rather than …

The addition to liver microsomes of various substrates, such as hexobarbital, aminopyrine,
or aniline, causes two types of spectral changes. Spectrophotometric studies suggest that …

Liver necrosis caused by CCl 4 is known to be decreased by the administration of SKF 525-A
(2-diethylaminoethyl 2,2-diphenylvalerate), Sch 5705 (ethyl 2-diethyl-aminoethyl-2-phenyl-…

… To determine whether the toxicity might be due to a reactive metabolite, [ 3 H]α-methyldopa
was incubated with rat liver microsomes in the presence of an NADPH-generating system. A …

Microsomes isolated from whole rat brain were found to contain cytochreme P-450 (0.025 to
0.051 nmoles/mg) and NADPH cytochrome c reductase activity (26.0 to 55.0 nmoles/mg/min)…

… Sasame and Boyd (7) previously have reported that concentrations of hepatic GSH were
elevated by prior treatments with cobaltous chloride or salts of several other divalent metals. …

… Also, a pretreatment (ie, starvation) that decreases gastric G~H enhances both stressinduced …
These observations led to our interest in the possible role of gastric G~H as a homeostatic, …

ABSTRACT MITCHELL, JR, WL NELSON, WZ POTFER, HA SASAME AND DJ JoLLow:
Metabolic activation of furosemide to a chemically reactive. hepatotoxic metabilite. J …

The following evidence suggests that the reduction of p-nitrobenzoate to p-aminobenzoate
by liver microsomes is mediated by cytochrome P. 450:(a) carbon monoxide blocks …

Amino acids were determined by ion exchange chromatography on soybean hulls, de-hulled
soybean meal, isolated soybean protein, and the residue; on whey proteins obtained by …