Interplay among immune activation and cancer pathogenesis provides the framework for a
novel subspecialty known as immunooncology. In the rapidly evolving field of …

Background This study evaluates the relationship between cytochrome P450 (CYP) 3A5
genotype and vincristine‐induced peripheral neuropathy (VIPN) in children with precursor B …

Clinical outcomes of vincristine therapy, both neurotoxicity and efficacy, are unpredictable,
and the reported pharmacokinetics of vincristine have considerable interindividual variability. …

Vincristine is preferentially metabolized to a secondary amine, M1, by CYP3A5 with a 9- to
14-fold higher intrinsic clearance than CYP3A4 using cDNA-expressed enzymes. The …

Background This report examines the association between race and vincristine‐associated
neurotoxicity in pediatric patients with precursor B cell acute lymphoblastic leukemia (preB …

Background Vincristine (VCR) is a critical part of treatment in pediatric malignancies and is
associated with dose‐dependent peripheral neuropathy (vincristine‐induced peripheral …

Objective To characterize the pharmacokinetics and pharmacogenetics of nifedipine in
pregnancy. Study Design Pregnant women receiving oral nifedipine underwent steady-state …

Background While most pediatric sarcomas respond to front-line therapy, some bone sarcomas
do not show radiographic response like soft-tissue sarcomas (rhabdomyosarccomas) but …

Vincristine is one of the core chemotherapy agents used in the treatment of pediatric acute
lymphoblastic leukemia ( ALL ). However, one of the major toxicities resulting from vincristine …

Simple Summary Solid tumors account for ~60% of pediatric, as well as adolescent and young
adult (AYA), cancers, and outcomes for patients with these progressive diseases remain …