Prodrugs: design and clinical applications

J Rautio, H Kumpulainen, T Heimbach… - Nature reviews Drug …, 2008 - nature.com
Prodrugs are bioreversible derivatives of drug molecules that undergo an enzymatic and/or
chemical transformation in vivo to release the active parent drug, which can then exert the …

The expanding role of prodrugs in contemporary drug design and development

J Rautio, NA Meanwell, L Di… - Nature reviews drug …, 2018 - nature.com
Prodrugs are molecules with little or no pharmacological activity that are converted to the
active parent drug in vivo by enzymatic or chemical reactions or by a combination of the two. …

Prodrugs—from serendipity to rational design

KM Huttunen, H Raunio, J Rautio - Pharmacological reviews, 2011 - ASPET
The prodrug concept has been used to improve undesirable properties of drugs since the late
19th century, although it was only at the end of the 1950s that the actual term prodrug was …

In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates

J Rautio, JE Humphreys, LO Webster… - Drug metabolism and …, 2006 - ASPET
Because modulation of P-glycoprotein (Pgp) through inhibition or induction can lead to drug-drug
interactions by altering intestinal, central nervous system, renal, or biliary efflux, it is …

[PDF][PDF] Dominant mutations in GRHL3 cause Van der Woude Syndrome and disrupt oral periderm development

…, P Unneberg, I Fransson, HK Koillinen, J Rautio… - The American Journal of …, 2014 - cell.com
Mutations in interferon regulatory factor 6 (IRF6) account for ∼70% of cases of Van der Woude
syndrome (VWS), the most common syndromic form of cleft lip and palate. In 8 of 45 VWS-…

Prodrugs in medicinal chemistry and enzyme prodrug therapies

R Walther, J Rautio, AN Zelikin - Advanced drug delivery reviews, 2017 - Elsevier
Prodrugs are cunning derivatives of therapeutic agents designed to improve the pharmacokinetics
profile of the drug. Within a prodrug, pharmacological activity of the drug is masked …

Prodrug approaches for CNS delivery

J Rautio, K Laine, M Gynther, J Savolainen - The AAPS journal, 2008 - Springer
Central nervous system (CNS) drug delivery remains a major challenge, despite extensive
efforts that have been made to develop novel strategies to overcome obstacles. Prodrugs are …

Large neutral amino acid transporter enables brain drug delivery via prodrugs

…, J Savolainen, T Järvinen, J Rautio - Journal of medicinal …, 2008 - ACS Publications
The blood−brain barrier efficiently controls the entry of drug molecules into the brain. We
describe a feasible means to achieve carrier-mediated drug transport into the rat brain via the …

Microtia in Finland: comparison of characteristics in different populations

…, J Rautio, A Ritvanen, S Ala-Mello, J Jero… - International journal of …, 2007 - Elsevier
OBJECTIVE: To compare the characteristics of microtia in Finland and in other populations.
METHODS: Retrospective case series and patient questionnaire of 190 microtia patients …

An electromagnetic time-harmonic analysis of shielded microstrip circuits

JC Rautio, RF Harrington - IEEE transactions on microwave …, 1987 - ieeexplore.ieee.org
A Galerkin analysis of microstrip circuits of arbitrary planar geometry enclosed in a rectangular
conducting box is described. The technique entails a time-harmonic electromagnetic …