Genetic findings and functional studies of human CYP3A5 single nucleotide polymorphisms in different ethnic groups

SJ Lee, KA Usmani, B Chanas… - Pharmacogenetics …, 2003 - journals.lww.com
Objectives Genetic polymorphisms of cytochromes P450 (CYPs) are a principal reason for
inter-individual variations in the metabolism of therapeutic drugs and environmental …

Inhibition and activation of the human liver microsomal and human cytochrome P450 3A4 metabolism of testosterone by deployment-related chemicals

KA Usmani, RL Rose, E Hodgson - Drug Metabolism and Disposition, 2003 - ASPET
Cytochrome P450 (P450) enzymes are major catalysts involved in the metabolism of xenobiotics
and endogenous substrates such as testosterone (TST). Major TST metabolites formed …

In vitro metabolism of fipronil by human and rat cytochrome P450 and its interactions with testosterone and diazepam

J Tang, KA Usmani, E Hodgson, RL Rose - Chemico-biological interactions, 2004 - Elsevier
Fipronil (5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile)
is a highly active, broad spectrum insecticide from the phenyl pyrazole …

In vitro sulfoxidation of thioether compounds by human cytochrome P450 and flavin-containing monooxygenase isoforms with particular reference to the CYP2C …

KA Usmani, ED Karoly, E Hodgson, RL Rose - Drug metabolism and …, 2004 - ASPET
Cytochrome P450 (P450) and flavin-containing monooxygenase (FMO) enzymes are major
catalysts involved in the metabolism of xenobiotics. The sulfoxidation of the thioether …

In vitro metabolism of carbofuran by human, mouse, and rat cytochrome P450 and interactions with chlorpyrifos, testosterone, and estradiol

KA Usmani, E Hodgson, RL Rose - Chemico-biological interactions, 2004 - Elsevier
Carbofuran is a carbamate pesticide used in agricultural practice throughout the world. Its
effect as a pesticide is due to its ability to inhibit acetylcholinesterase activity. Though …

Toxicity of Pyrethroids and Effect of Synergists to Larval and Adult Helicoverpa zea, Spodoptera frugiperda, and Agrotis ipsilon(Lepidoptera: Noctuidae)

KA Usmani, CO Knowles - Journal of Economic Entomology, 2001 - academic.oup.com
Based on 48 h LD 50 estimates from topical bioassays, cypermethrin was more toxic than
permethrin to Helicoverpa zea (Boddie) larvae and adults; however, the two pyrethroids did …

Inhibition of the human liver microsomal and human cytochrome P450 1A2 and 3A4 metabolism of estradiol by deployment-related and other chemicals

KA Usmani, TM Cho, RL Rose, E Hodgson - Drug Metabolism and …, 2006 - ASPET
… TST and its metabolite, 6β-hydroxytestosterone, were separated using the method described
by Usmani et al. (2003). E 2 and its metabolites eluted after 6β-hydroxytestosterone and …

Towards a taxonomy of cyber threats against target applications

B Narwal, AK Mohapatra, KA Usmani - Journal of Statistics and …, 2019 - Taylor & Francis
As the adoption of ubiquitous computing is growing with rapid pace, its security is becoming
a major concern due to nimble and creative cyber attackers. The evolving threats are …

In vitro human metabolism and interactions of repellent N, N-diethyl-m-toluamide

KA Usmani, RL Rose, JA Goldstein, WG Taylor… - Drug metabolism and …, 2002 - ASPET
Oxidative metabolism of the insect repellentN,N-diethyl-m-toluamide (DEET) by pooled
human liver microsomes (HLM), rat liver microsomes (RLM), and mouse liver microsomes (MLM) …

Human cytochrome P450: metabolism of testosterone by CYP3A4 and inhibition by ketoconazole

KA Usmani, J Tang - Current protocols in toxicology, 2004 - Wiley Online Library
This unit describes methods for measuring CYP3A4 activity using testosterone as a specific
substrate, and for measuring CYP3A4 inhibition using ketoconazole as a selective inhibitor …