Als erstes dieser Art in Deutschland zielt das Modellprojekt „Qualitätsmonitoring in der
ambulanten Psychotherapie” darauf ab, ein modifiziertes Qualitätssicherungs-und …

Background The cardiac effects of statins are subject to controversial discussion, and the
mechanism of their uptake into the human heart is unknown. A candidate protein is the organic …

Like other members of the multidrug resistance protein (MRP)/ABCC subfamily of ATP-binding
cassette transporters, MRP4 (ABCC4) and MRP5 (ABCC5) are organic anion transporters…

BACKGROUND: While highlighting the efficacy of different treatments for major depressive
disorders (MDD), findings of the National Institute of Mental Health (NIMH) Treatment of …

Detailed knowledge regarding the influence of hepatic transport proteins on drug disposition
has advanced at a rapid pace over the past decade. Efflux transport proteins located in the …

… The K m values estimated for MRP3 (9.1 µM) and MRP4 (3.5 µM) were consistent with
previously reported K m values of 17–43 µM for MRP3 (Zelcer et al., 2001; Akita et al., 2002), and …

The human placenta has both protective and nurturing functions for the fetal organism.
Uptake and elimination of xenobiotics and endogenous substances are facilitated by various …

Purpose: Successful treatment of acute myeloid leukemia (AML) remains a therapeutic
challenge, with a high percentage of patients suffering from persistent or relapsed disease. …

Introduction. It is internationally agreed that diabetes mellitus (DM) is associated with increased
maternal and fetal morbidity and long-term complications. To avoid these complications, …

Drug-induced cholestasis is an important form of acquired liver disease and is associated
with significant morbidity and mortality. Bile acids are key signaling molecules, but they can …