User profiles for K. Prokai-Tatrai
Katalin Prokai-TatraiDepartment of Pharmacology and Neuroscience, UNTHSC Verified email at unthsc.edu Cited by 2600 |
Targeting drugs to the brain by redox chemical delivery systems
L Prokai, K Prokai‐Tatrai… - Medicinal research reviews, 2000 - Wiley Online Library
Chemical delivery systems (CDSs) based on the redox conversion of a lipophilic dihydropyridine
to an ionic, lipid‐insoluble pyridinium salt have been developed to improve the access …
to an ionic, lipid‐insoluble pyridinium salt have been developed to improve the access …
Mechanistic insights into the direct antioxidant effects of estrogens
Free‐radical scavenging by estrogens has been implicated as one of their non‐genomic (estrogen‐receptor
independent) mechanisms of cytoprotection. This activity is associated with …
independent) mechanisms of cytoprotection. This activity is associated with …
Quinol-based cyclic antioxidant mechanism in estrogen neuroprotection
Substantial evidence now exists that intrinsic free-radical scavenging contributes to the
receptor-independent neuroprotective effects of estrogens. This activity is inherently associated …
receptor-independent neuroprotective effects of estrogens. This activity is inherently associated …
17β-Estradiol Eye Drops Protect the Retinal Ganglion Cell Layer and Preserve Visual Function in an in Vivo Model of Glaucoma
Neuroprotection in glaucoma as a curative strategy complementary to current therapies to
lower intraocular pressure (IOP) is highly desirable. This study was designed to investigate …
lower intraocular pressure (IOP) is highly desirable. This study was designed to investigate …
Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2, 4-dimethoxy) benzylidene]-anabaseine dihydrochloride (GTS-21): their molecular properties, interactions …
…, S LeFrancois, K Wildeboer, K Prokai-Tatrai… - Molecular …, 2004 - ASPET
… All K i values were calculated from the Cheng-Prusoff equation, using a K d value for each
radioligand that had been experimentally determined under conditions identical with those of …
radioligand that had been experimentally determined under conditions identical with those of …
Mechanistic investigations on the antioxidant action of a neuroprotective estrogen derivative
K Prokai-Tatrai, P Perjesi, NM Rivera-Portalatin… - Steroids, 2008 - Elsevier
Antioxidant action is an important component of the complex neuroprotective effect of
estrogens. Combining theoretical prediction and subsequent experimental confirmation by …
estrogens. Combining theoretical prediction and subsequent experimental confirmation by …
[HTML][HTML] A novel prodrug approach for central nervous system-selective estrogen therapy
K Prokai-Tatrai, L Prokai - Molecules, 2019 - mdpi.com
Beneficial effects of estrogens in the central nervous system (CNS) results from the synergistic
combination of their well-orchestrated genomic and non-genomic actions, making them …
combination of their well-orchestrated genomic and non-genomic actions, making them …
The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders
…, I Merchenthaler, P Koulen, K Prokai-Tatrai - Science Translational …, 2015 - science.org
Many neurological and psychiatric maladies originate from the deprivation of the human brain
from estrogens. However, current hormone therapies cannot be used safely to treat these …
from estrogens. However, current hormone therapies cannot be used safely to treat these …
[HTML][HTML] Factors that contribute to the misidentification of tyrosine nitration by shotgun proteomics
The high selectivity and throughput of tandem mass spectrometry allow for rapid identification
and localization of various posttranslational protein modifications from complex mixtures …
and localization of various posttranslational protein modifications from complex mixtures …
Brain-targeted delivery of a leucine-enkephalin analogue by retrometabolic design
K Prokai-Tatrai, L Prokai, N Bodor - Journal of medicinal chemistry, 1996 - ACS Publications
… Half-lives (t 1/2 ) were calculated from the rate constants (k) as 0.693/k. Representative
samples were desalted on a reversed phase minicolumn (1-mL Supelclean LC-18, Supelco, …
samples were desalted on a reversed phase minicolumn (1-mL Supelclean LC-18, Supelco, …