User profiles for K. Prokai-Tatrai

Katalin Prokai-Tatrai

Department of Pharmacology and Neuroscience, UNTHSC
Verified email at unthsc.edu
Cited by 2600

Targeting drugs to the brain by redox chemical delivery systems

L Prokai, K ProkaiTatrai… - Medicinal research reviews, 2000 - Wiley Online Library
Chemical delivery systems (CDSs) based on the redox conversion of a lipophilic dihydropyridine
to an ionic, lipid‐insoluble pyridinium salt have been developed to improve the access …

Mechanistic insights into the direct antioxidant effects of estrogens

L Prokai, K ProkaiTatrai, P Perjési… - Drug development …, 2005 - Wiley Online Library
Free‐radical scavenging by estrogens has been implicated as one of their non‐genomic (estrogen‐receptor
independent) mechanisms of cytoprotection. This activity is associated with …

Quinol-based cyclic antioxidant mechanism in estrogen neuroprotection

L Prokai, K Prokai-Tatrai, P Perjesi… - Proceedings of the …, 2003 - National Acad Sciences
Substantial evidence now exists that intrinsic free-radical scavenging contributes to the
receptor-independent neuroprotective effects of estrogens. This activity is inherently associated …

17β-Estradiol Eye Drops Protect the Retinal Ganglion Cell Layer and Preserve Visual Function in an in Vivo Model of Glaucoma

K Prokai-Tatrai, H Xin, V Nguyen, S Szarka… - Molecular …, 2013 - ACS Publications
Neuroprotection in glaucoma as a curative strategy complementary to current therapies to
lower intraocular pressure (IOP) is highly desirable. This study was designed to investigate …

Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2, 4-dimethoxy) benzylidene]-anabaseine dihydrochloride (GTS-21): their molecular properties, interactions …

…, S LeFrancois, K Wildeboer, K Prokai-Tatrai… - Molecular …, 2004 - ASPET
… All K i values were calculated from the Cheng-Prusoff equation, using a K d value for each
radioligand that had been experimentally determined under conditions identical with those of …

Mechanistic investigations on the antioxidant action of a neuroprotective estrogen derivative

K Prokai-Tatrai, P Perjesi, NM Rivera-Portalatin… - Steroids, 2008 - Elsevier
Antioxidant action is an important component of the complex neuroprotective effect of
estrogens. Combining theoretical prediction and subsequent experimental confirmation by …

[HTML][HTML] A novel prodrug approach for central nervous system-selective estrogen therapy

K Prokai-Tatrai, L Prokai - Molecules, 2019 - mdpi.com
Beneficial effects of estrogens in the central nervous system (CNS) results from the synergistic
combination of their well-orchestrated genomic and non-genomic actions, making them …

The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders

…, I Merchenthaler, P Koulen, K Prokai-Tatrai - Science Translational …, 2015 - science.org
Many neurological and psychiatric maladies originate from the deprivation of the human brain
from estrogens. However, current hormone therapies cannot be used safely to treat these …

[HTML][HTML] Factors that contribute to the misidentification of tyrosine nitration by shotgun proteomics

SM Stevens, K Prokai-Tatrai, L Prokai - Molecular & Cellular Proteomics, 2008 - ASBMB
The high selectivity and throughput of tandem mass spectrometry allow for rapid identification
and localization of various posttranslational protein modifications from complex mixtures …

Brain-targeted delivery of a leucine-enkephalin analogue by retrometabolic design

K Prokai-Tatrai, L Prokai, N Bodor - Journal of medicinal chemistry, 1996 - ACS Publications
… Half-lives (t 1/2 ) were calculated from the rate constants (k) as 0.693/k. Representative
samples were desalted on a reversed phase minicolumn (1-mL Supelclean LC-18, Supelco, …