Pregabalin has shown clinical efficacy for treatment of neuropathic pain syndromes, partial
seizures, and anxiety disorders. Five studies in healthy volunteers are performed to …

Gabapentin, an analog of y-aminobutyric acid, exhibits anticonvul-sant properties in both
animal models and humans. Gabapentin pharmacokinetics was studied in laboratory animals …

Gabapentin (GBP) is a non-metabolized, non-plasma protein bound, renally excreted
antiepileptic drug that is actively absorbed via the system L amino acid transporter. Previous …

Tolerance and pharmacokinetics after single‐dose administration of atorvastatin, an investigational
inhibitor of HMG‐CoA reductase, were examined in 22 healthy volunteers in a three‐…

Pregabalin (Lyrica™) is a novel amino acid compound that binds with high affinity to the
alpha 2 –delta (α 2 –δ) auxiliary protein of voltage-gated calcium channels. In vivo, it potently …

… WOOLF AND RADULOVIC … WOOLF AND RADULOVIC … [ll] to show an interaction
between aspirin and sudoxicam in monkeys and man were unsuccessful. …

To determine whether atorvastatin, a new HMG‐CoA reductase inhibitor, could be administered
with food in Phase II and III clinical trials, a nonblind, randomized, two‐way crossover …

… Los niveles plasmaticos medios basales de la CBZ y la CBZ 10,ll-epoxido (CBZ-E) y las
cocentraciones sericas de VPA antes, durante y desputs de la administracion de GBP no …

Materials and Methods Chemicals. Radiolabeled TBR was synthesized by Amersham Corp.(Arlington
Heights, IL) with 4C located at position 8 of the xanthine ring. This material had a …

A simple High Performance Liquid Chromatography procedure is detailed for the purification
of Glutathione S-transferase. The human placental transferase was used to assess its …