Nuclear hormone receptors comprise a superfamily of ligand-modulated transcription factors
that mediate the transcriptional activities of steroids, retinoids, and thyroid hormones. A …

In order to address data gaps identified by the NAS report Pesticides in the Diets of Infants
and Children, a study was performed using methoxychlor (MXC). Female rats were gavaged …

RXR is a nuclear receptor that plays a central role in cell signaling by pairing with a host of
other receptors. Previously, 9-cis-retinoic acid (9cRA) was defined as a potent RXR activator. …

In a recently completed 2‐yr bioassay, furan was found to induce cholangiocarcinomas at
high incidence in rats. The disposition of single and multiple gavage doses of [2,5‐ 14 C]furan …

An important mechanism of toxicity of furans involves the cytochrome P-450
monooxygenase-catalyzed bioactivation of the compound in situ directly within the target tissues to …

Polybrominated diphenyl ethers (PBDEs), used as flame retardants, have been detected in
the environment and in mammalian tissues and fluids. Evidence indicates that PBDE …

(5-Hydroxymethyl)furfural (HMF), a heat-induced decomposition product of hexoses, is present
in food and drink. Recent reports have shown HMF to be an in vitro mutagen after sulfate …

The cytochrome P-450 enzymes are a family of heme-containing proteins involved in the
metabolism of a range of substances that possess great diversity in structure. These …

In National Toxicology Program 2-year studies, hexavalent chromium [Cr(VI)] administered
in drinking water was clearly carcinogenic in male and female rats and mice, resulting in …

Reported adverse drug interactions with the popular herb kava have spurred investigation of
the mechanisms by which kava could mediate these effects. In vivo and in vitro experiments …