Foreign compound metabolism by isolated skin cells from the hairless mouse.

MW Coomes, AH Norling, RJ Pohl, D Müller… - Journal of Pharmacology …, 1983 - ASPET
A method for isolating mouse skin cells by enzymatic digestion with trypsin was developed.
Cell populations of 33% viability could be further separated by metrizamide and Percoll …

[PDF][PDF] The mitochondrial metabolism of 1, 2-disubstituted hydrazines, procarbazine and 1, 2-dimethylhydrazine.

MW Coomes, RA Prough - Drug metabolism and disposition, 1983 - Citeseer
Sonication of isolated rat hepatocytes caused a pronounced decrease in the mtabollsm of
biphenyl due to dilution of the cytosolic pool of NADPH, but did not greatly reduce the rate of …

7-ethoxycoumarin O-deethylation activity in viable basal and differentiated keratinocytes isolated from the skin of the hairless mouse.

RJ Pohl, MW Coomes, RW Sparks, JR Fouts - Drug metabolism and …, 1984 - ASPET
Epidermal cells in suspension were prepared from the skin of hairless mice by digestion of
skin strips with pronase. The viability of cells in such suspensions was routinely greater than …

Oxidation of 7-ethoxycoumarin and conjugation of umbelliferone by intact, viable epidermal cells from the hairless mouse

MW Coomes, RW Sparks, JR Fouts - Journal of Investigative Dermatology, 1984 - Elsevier
Intact, viable (>80%) epidermal cells were isolated from the hairless mouse. These cells
metabolized 7-ethoxycoumarin (7-EC) to umbelliferone (UMB) (3 pmol/min/10 6 cells) and UMB …

Properties of an Escherichia coli mutant deficient in phosphoenolpyruvate carboxylase catalytic activity

MW Coomes, BK Mitchell, A Beezley… - Journal of …, 1985 - Am Soc Microbiol
… from the Vmax data for the acetyl coenzyme A experiment and the enzyme (protein) equivalents
calculated above, a catalytic constant of 4.6 x 103/min (based on a molecular weight of …

Isolation and sequence of the phosphoenolpyruvate carboxylase gene of the marine cyanobacterium Synechococcus PCC 7002

AA Smith, MW Coomes, TE Smith - 2008 - agris.fao.org
The pepc gene, which encodes phosphoenolpyruvate carboxylase (PEPC), of the marine
cyanobacterium Synechococcus PCC 7002, was isolated and sequenced. PEPC is an …

The metabolism of 1, 2-disubstituted hydrazines in isolated hepatocytes

MW Coomes, P Wiebkin, RA Prough - Microsomes, Drug Oxidations and …, 1980 - Elsevier
Publisher Summary This chapter discusses the metabolism of 1, 2-disubstituted hydrazines
in isolated hepatocytes. The cancer chemotherapeutic agent procarbazine (PCZ), that is, a 1,…

PEGASUS-A multi-megawatt nuclear electric propulsion system

E COOMES, J CUTA, B WEBB, D KING - 22nd Joint Propulsion …, 1986 - arc.aiaa.org
… It is capable of providing a maximum of 8.5 megawatts of electrical power of which 6
megawatts is needed for the thruster system, 1.5 megawatts is available for spacecraft system …

Angiosperm wood structure: global patterns in vessel anatomy and their relation to wood density and potential conductivity

…, SR Loarie, SEJ Arnold, DA Coomes - American Journal of …, 2010 - Wiley Online Library
… the ARC-NZ Research Network for Vegetation Function (http://www.vegfunction.net/) for
initiating the vascular design working group that led to the collaboration between DAC, DSF, MW

A Modern Day Perspective on the Work of Charles Darwin

TE Smith, MW Coomes - Journal of the Washington Academy of Sciences, 2009 - JSTOR
That many and grave objections may be advanced against the theory of descent with
modification through natural selection, I do not deny. I have endeavoured to give to them their lull …