Prediction of the disposition of nine weakly acidic and six weakly basic drugs in humans from pharmacokinetic parameters in rats

Y Sawada, M Hanano, Y Sugiyama, T Iga - Journal of pharmacokinetics …, 1985 - Springer
… Iga, and M. Hanano. Prediction of diazepam disposition in the rat and man by a physiologically
based … Hanano. In vitro and in vivo assessment of hepatic and extrahepatic metabolism of …

Contribution of fractures to formation and production of geothermal resources

M Hanano - Renewable and Sustainable Energy Reviews, 2004 - Elsevier
… Since the temperature gradient at well (3) is about 0.2 K/m, the heat flux is approximately
0.4 W/m 2 , assuming that the thermal conductivity of the rock medium is about 2 W/m K. This is …

Receptor-mediated transport of peptide hormones and its importance in the overall hormone disposition in the body

Y Sugiyama, M Hanano - Pharmaceutical research, 1989 - Springer
A remarkable feature of the pharmacokinetics of polypeptide hormones is the contribution of
specific binding sites (receptors) to the polypeptide hormone distribution and clearance in …

In vitro andin vivo evaluation of the tissue-to-blood partition coefficient for physiological pharmacokinetic models

JH Lin, Y Sugiyama, S Awazu, M Hanano - Journal of pharmacokinetics …, 1982 - Springer
… Awazu, and M. Hanano. Correlation between in vitro and in vivo drug metabolism rate: …
Hanano. Physiological pharmacokinetics of ethoxybenzamide based on biochemical data …

Prediction of the volumes of distribution of basic drugs in humans based on data from animals

Y Sawada, M Hanano, Y Sugiyama… - … of pharmacokinetics and …, 1984 - Springer
… Iga, and M. Hanano. Effect of sulphaphenazole on tolbutamide distribution in rabbits. Analysis
M. Brinkschulte and UB Pfaff. Binding of tricyclic antidepressants and perazine to human …

Na (+)-independent multispecific anion transporter mediates active transport of pravastatin into rat liver

M Yamazaki, H Suzuki, M Hanano… - American Journal …, 1993 - journals.physiology.org
… lo-20 min, and the C/M ratio at the equilibriu m measured at 20 min was 18.0. At this time (…
The C/M ratio was corrected for these estimates. As a result, the equilibrium C/M ratio was …

Prediction of diazepam disposition in the rat and man by a physiologically based pharmacokinetic model

…, Y Sugiyama, Y Sawada, T Iga, M Hanano - … of pharmacokinetics and …, 1983 - Springer
… Iga, and M. Hanano. Tissue distribution of 14Cdiazepam and its metabolities in the rat.
Drug… Hanano. In vitro and in vivo assessment of hepatic and extrahepatic metabolism of …

Care coordination between rural primary care and telemedicine to expand medication treatment for opioid use disorder: Results from a single‐arm, multisite feasibility …

…, Y Liu, NA Ha, SM Murphy, M Hanano… - The Journal of Rural …, 2023 - Wiley Online Library
Purpose The use of telemedicine (TM) has accelerated in recent years, yet research on the
implementation and effectiveness of TM‐delivered medication treatment for opioid use …

Circulating thrombomodulin as a novel endothelial cell marker: Comparison of its behavior with von Willebrand factor and tissue‐type plasminogen activator

H Takahashi, S Ito, M Hanano, K Wada… - American journal of …, 1992 - Wiley Online Library
Circulating thrombomodulin is a novel endotheliai cell marker, which may reflect the
endothelial injury. Plasma levels of thrombomodulin were quantitated by an enzymelinked …

Importance of the liver in plasma clearance of hepatocyte growth factors in rats

…, M Narukawa, DC Kim, M Hanano… - American Journal …, 1992 - journals.physiology.org
After intravenous administration of 125I-labeled hepatocyte growth factor (HGF), trichloroacetic
acid-precipitable radioactivity in the plasma disappeared rapidly with an early phase half-…