Comparison of butyrylcholinesterase and acetylcholinesterase.
A Chatonnet, O Lockridge - Biochemical Journal, 1989 - ncbi.nlm.nih.gov
INTRODUCTION In vertebrates two different enzymes hydrolyse acetylcholine.
Acetylcholinesterase (EC 3.1. 1.7; AChE) termi-nates the action of acetylcholine at the post-synaptic …
Acetylcholinesterase (EC 3.1. 1.7; AChE) termi-nates the action of acetylcholine at the post-synaptic …
Review of human butyrylcholinesterase structure, function, genetic variants, history of use in the clinic, and potential therapeutic uses
O Lockridge - Pharmacology & therapeutics, 2015 - Elsevier
Phase I clinical trials have shown that pure human butyrylcholinesterase (BChE) is safe
when administered to humans. A potential therapeutic use of BChE is for prevention of nerve …
when administered to humans. A potential therapeutic use of BChE is for prevention of nerve …
Butyrylcholinesterase for protection from organophosphorus poisons: catalytic complexities and hysteretic behavior
P Masson, O Lockridge - Archives of biochemistry and biophysics, 2010 - Elsevier
… out in 18 O-water and compared to aging in 16 O-water. Analysis of tryptic peptides by
MALDI-TOF mass spectrometry provided evidence that dealkylation occurs by breaking of the …
MALDI-TOF mass spectrometry provided evidence that dealkylation occurs by breaking of the …
[HTML][HTML] Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products
Y Nicolet, O Lockridge, P Masson… - Journal of Biological …, 2003 - ASBMB
Cholinesterases are among the most efficient enzymes known. They are divided into two
groups: acetylcholinesterase, involved in the hydrolysis of the neurotransmitter acetylcholine, …
groups: acetylcholinesterase, involved in the hydrolysis of the neurotransmitter acetylcholine, …
Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine
Acetylcholinesterase is one of the most prominent constituents of central cholinergic pathways.
It terminates the synaptic action of acetylcholine through hydrolysis and yields the choline …
It terminates the synaptic action of acetylcholine through hydrolysis and yields the choline …
Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma
…, EG Duysen, P Masson, O Lockridge - Biochemical …, 2005 - Elsevier
The goal of this work was to identify the esterases in human plasma and to clarify common
misconceptions. The method for identifying esterases was nondenaturing gradient gel …
misconceptions. The method for identifying esterases was nondenaturing gradient gel …
[HTML][HTML] Complete amino acid sequence of human serum cholinesterase.
O Lockridge, CF Bartels, TA Vaughan, CK Wong… - Journal of Biological …, 1987 - Elsevier
… Ala 1832 Gln 111 Gln 739 br 31 Ro 654 Uu 61 561 R o 681 Gly Ug Lu 238 Lu 241 Ug 199 95
155 154 5 Glu … IS O f 0 M . L nd fm dlgestlon ria I..YL.… IS O f 0 M . L nd fm dlgestlon ria I..YL.…
155 154 5 Glu … IS O f 0 M . L nd fm dlgestlon ria I..YL.… IS O f 0 M . L nd fm dlgestlon ria I..YL.…
Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse
…, S Brimijoin, SH Hinrichs, O Lockridge - Journal of …, 2000 - Wiley Online Library
… Jbilo O., Bartels CF, Chatonnet A., Toutant J.-P., and Lockridge O. (1994) Tissue distribution
… Lockridge O. (1990) Genetic variants of human serum cholinesterase influence metabolism …
… Lockridge O. (1990) Genetic variants of human serum cholinesterase influence metabolism …
Differences in active site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase
A Saxena, AMG Redman, X Jiang, O Lockridge… - Biochemistry, 1997 - ACS Publications
… with inhibitors were compared using LSQ utilities of program O ( 26). The calculations of the
… of O ( 26), and all of the possible rotamers for each mutation as defined in the database of O …
… of O ( 26), and all of the possible rotamers for each mutation as defined in the database of O …
Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase
…, P Taylor, SH Hinrichs, O Lockridge - Journal of …, 2000 - ASPET
Acetylcholinesterase (AChE; EC 3.1.1.7 ) is the primary terminator of nerve impulse transmission
at cholinergic synapses and is believed to play an important role in neural development…
at cholinergic synapses and is believed to play an important role in neural development…