[HTML][HTML] Bioengineered kidney tubules efficiently excrete uremic toxins

…, JG Peters, UM Kreuser, PH Van Den Broek… - Scientific reports, 2016 - nature.com
The development of a biotechnological platform for the removal of waste products (eg uremic
toxins), often bound to proteins in plasma, is a prerequisite to improve current treatment …

[HTML][HTML] The influence of dietary protein intake on mammalian tryptophan and phenolic metabolites

…, HAM Mutsaers, K Windey, PH Van Den Broek… - PLoS …, 2015 - journals.plos.org
van den Broek, … van den Broek, … Pedrini MT, Levey AS, Lau J, Chalmers TC, Wang PH.
The effect of dietary protein restriction on the progression of diabetic and nondiabetic renal …

Effects of hypothermia on pharmacokinetics and pharmacodynamics: a systematic review of preclinical and clinical studies

MPH van den Broek, F Groenendaal… - Clinical …, 2010 - Springer
pH of 7.4 and a pCO 2 of 5.3 kPa (40 mmHg) [pH-stat].[44] In contrast, in the alpha-stat method,
the blood pH is adjusted to a pH of … and adverse effects, the pH-stat method seems to be …

Allogeneic mesenchymal stem cells stimulate cartilage regeneration and are safe for single-stage cartilage repair in humans upon mixture with recycled autologous …

…, MPH van den Broek, R Nizak, MHP van Rijen… - Stem …, 2017 - academic.oup.com
Traditionally, mesenchymal stem cells (MSCs) isolated from adult bone marrow were
described as being capable of differentiating to various lineages including cartilage. Despite …

Clinical management of seizures in newborns: diagnosis and treatment

LGM van Rooij, MPH van den Broek, CMA Rademaker… - Pediatric Drugs, 2013 - Springer
Neonatal seizures can be classified as tonic, clonic, myoclonic, and subtle. A clinical diagnosis
is not easy as seizures are usually subtle in neonates. In the majority of newborn infants …

[HTML][HTML] Intrathecal trastuzumab versus alternate routes of delivery for HER2-targeted therapies in patients with HER2+ breast cancer leptomeningeal metastases

…, S Hofer, W Jacot, HJ Stemmler, MPH van den Broek… - The Breast, 2023 - Elsevier
Background Patients with HER2+ breast cancer (BC) frequently develop leptomeningeal
metastases (LM). While HER2-targeted therapies have demonstrated efficacy in the …

How systemic inflammation modulates adenosine metabolism and adenosine receptor expression in humans in vivo

…, KE Wever, M Kox, PH van den Broek… - Critical care …, 2012 - journals.lww.com
Objective: Adenosine modulates inflammation and prevents associated organ injury by
activation of its receptors. During sepsis, the extracellular adenosine concentration increases …

[HTML][HTML] Uremic solutes in chronic kidney disease and their role in progression

…, AD van Zuilen, PJ Blankestijn, PH van den Broek… - PLoS …, 2016 - journals.plos.org
van den Broek, … van den Broek, … However, compared to the patients in the studies by
Niewczas et al. and Van der Kloet et al., our patients had more advanced CKD. Other metabolic …

[HTML][HTML] Impact of metformin on endothelial ischemia-reperfusion injury in humans in vivo: a prospective randomized open, blinded-endpoint study

…, RD Kengen, GA Rongen, PH van den Broek… - PloS one, 2014 - journals.plos.org
van den Broek, … van den Broek, … Citation: El Messaoudi S, Schreuder TH, Kengen RD,
Rongen GA, van den Broek PH, Thijssen DHJ, et al. (2014) Impact of Metformin on Endothelial …

Lidocaine response rate in aEEG‐confirmed neonatal seizures: retrospective study of 413 full‐term and preterm infants

…, L Hellström‐Westas, MPH Van Den Broek… - …, 2016 - Wiley Online Library
… study by van den Broek et al.,16 all infants received lidocaine as third-line AED, possibly
explaining the higher response rate. Furthermore, all infants in the study by van den Broek et al.…