3-(1,1-Dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, Potent Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase

R Tedesco, AN Shaw, R Bambal, D Chai… - Journal of medicinal …, 2006 - ACS Publications
Recently, we disclosed a new class of HCV polymerase inhibitors discovered through high-throughput
screening (HTS) of the GlaxoSmithKline proprietary compound collection. This …

Characterization and inhibition of a cholecystokinin-inactivating serine peptidase

…, F Vargas, P Facchinetti, P Bourgeat, RB Bambal… - Nature, 1996 - nature.com
R', we first optimized P, thereby selecting the unnatural amino acid 5-2-aminobutyric acid
(Abu). We then optimized R… affinity, which suggests that R" contributes a hydrophobic binding …

Candidate Selection and Preclinical Evaluation of N-tert-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century

…, R Bonar-Law, S Hindley, RB Bambal… - Journal of medicinal …, 2009 - ACS Publications
N-tert-Butyl isoquine (4) (GSK369796) is a 4-aminoquinoline drug candidate selected and
developed as part of a public−private partnership between academics at Liverpool, MMV, and …

Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4′-fluoro and 4′-chloro analogues of amodiaquine. Identification of a suitable “ …

…, PA Winstanley, S Hindley, RB Bambal… - Journal of medicinal …, 2009 - ACS Publications
On the basis of a mechanistic understanding of the toxicity of the 4-aminoquinoline
amodiaquine (1b), three series of amodiaquine analogues have been prepared where the 4-…

Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding

…, CW Andrews, JGB Alberti, R Bambal… - Bioorganic & medicinal …, 2009 - Elsevier
… Badiang Alberti a , Ramesh Bambal b , Stanley D. Chamberlain a , Ronda G. Davis-Ward
a , Hamilton D. … Installation of a methyl group at the benzylic carbon in the R-configuration …

Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase

AN Shaw, R Tedesco, R Bambal, D Chai… - Bioorganic & medicinal …, 2009 - Elsevier
… Interestingly, the (S)-enantiomer 12o is weaker biochemically, as was predicted by prior
modeling studies showing a small pocket for a group in the (R)-configuration but not for the one …

[PDF][PDF] An outbreak of buffalopox in buffalo (Bubalus bubalis) dairy herds in Aurangabad, India

…, KR Shingal, SB Tatwarti, RG Bambal… - Revue Scientifique et …, 2006 - researchgate.net
An outbreak of buffalopox in domestic buffaloes, with high morbidity and significant production
loss, was recorded in the Aurangabad district of Maharashtra State in India in November …

Brucellosis in India: Results of a collaborative workshop to define One Health priorities

…, RA Hazarika, H Rahman, RG Bambal… - Tropical animal health …, 2020 - Springer
Brucellosis is an important zoonosis worldwide. In livestock, it frequently causes chronic
disease with reproductive failures that contribute to production losses, and in humans, it causes …

Preclinical drug metabolism and pharmacokinetic evaluation of GW844520, a novel anti‐malarial mitochondrial electron transport inhibitor

…, GS Moorthy, E Hugger, R Bambal… - Journal of …, 2006 - Wiley Online Library
GW844520 is a potent and selective inhibitor of the cytochrome bc1 complex of mitochondrial
electron transport in P. falciparum, the parasite primarily responsible for the mortality …

Synthesis of N. epsilon.-(p-Bromophenyl)-L-lysine and N. tau.-(p-Bromophenyl)-L-histidine as Models for Adducts of Bromobenzene 3, 4-Oxide to Protein. Observation …

R Bambal, RP Hanzlik - The Journal of Organic Chemistry, 1994 - ACS Publications
… Nevertheless, this approach seemed reasonable for the introduction of an aryl substituent
onto the r-nitrogen of histidine, so we adapted it for the synthesis of 8, which was ultimately …