… In addition, Lu and West (32) have shown that 7,8-benzoflavone inhibits the cytochrome P-448-
supported hydroxylation of benzo[a]pyrene but not the cyto- chrome P-450-mediated …

The interaction between cytochrome P-450 and NADPH-cytochrome c reductase during
catalysis has been investigated with a reconstituted monooxygenase system composed of the …

Cytochrome P-448 from 3-methylcholanthrene-treated rats has been purified to a specific
content of greater than 20 nmoles/mg protein, and cytochrome P-450 from phenobarbital-…

JOSEPH & LEVIN, WAYNE(1976) Immunochemical evidence for six forms ofrat liver cytochrome
P450 obtained using antibodies against purified rat liver cytochromes P450 and P448. …

Studies of mammalian mixed-function oxidase activity have been conducted with biological
systems ranging in complexity from the intact animal or perfused whole organ to isolated …

1. The role of cytochrome b 5 in the oxidative metabolism of benzphetamine and 3,4-benzpyrene
in the presence of NADPH was studied with the reconstituted hydroxylation system …

… Author links open overlay panel MT Huang , SB West , AY Lu … WEST, AND ANTHONY YH
Lu From the Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche Inc., Nutley…

Benzo[a]anthracena and the 5 metabolically possible trans dihydrodiols of benzo[a]anthracene
were metabolized, in the presence of S.thyphimurium strain TA100, by a highly purified …

A rapid and simple procedure has been developed for the purification of a phenobarbital-inducible
form of cytochrome P-450 from the liver microsomes of phenobarbitalpretreated rats. …

An enzyme system in rat liver microsomes which catalyzes the NADH-dependent hydroxylation
of 3,4-benzpyrene has been reconstituted. The essential components of this NADH-…