Current progress on esterases: from molecular structure to function

T Satoh, P Taylor, WF Bosron, SP Sanghani… - Drug Metabolism and …, 2002 - ASPET
This article reports on a symposium sponsored by the American Society for Pharmacology
and Experimental Therapeutics and held at the April 2001 Experimental Biology meeting. …

Human carboxylesterases: an update on CES1, CES2 and CES3

SP Sanghani, PC Sanghani, MA Schiel… - Protein and peptide …, 2009 - ingentaconnect.com
Carboxylesterases belong to Phase I group of drug metabolizing enzymes. They hydrolyze
a variety of drug esters, amides, carbamates and similar structures. There are five ‘…

Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1

Z Sun, DJ Murry, SP Sanghani, WI Davis… - … of Pharmacology and …, 2004 - ASPET
Methylphenidate is an important stimulant prescribed to treat attention-deficit hyperactivity
disorder. It has two chiral centers, but most current commercial formulations consist of the …

Hydrolysis of capecitabine to 5′-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide

SK Quinney, SP Sanghani, WI Davis, TD Hurley… - … of Pharmacology and …, 2005 - ASPET
… We thank Paresh Sanghani for assistance with this manuscript and the Protein Expression
Core of Indiana University School of Medicine for providing purified carboxylesterase …

Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis

SP Sanghani, SK Quinney, TB Fredenburg, Z Sun… - Clinical Cancer …, 2003 - AACR
Purpose: The purpose is to develop new analytical methods to study the expression profile
of CPT-11 carboxylesterases and topoisomerase I in colon tumor samples and understand …

Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino) …

SP Sanghani, SK Quinney, TB Fredenburg… - Drug Metabolism and …, 2004 - ASPET
… Based on the exposure time and determination of relative expression in colon tissue (Sanghani
et al., 2003), we conclude that the abundance of CES3 is much less than that of CES2 in …

Maternal separation and handling affects cocaine self-administration in both the treated pups as adults and the dams

MC Moffett, J Harley, D Francis, SP Sanghani… - … of Pharmacology and …, 2006 - ASPET
Repeated maternal separation of pups from dams is often used as an early life stressor that
causes profound neurochemical and behavioral changes in the pups that persist into …

[HTML][HTML] Kinetic and cellular characterization of novel inhibitors of S-nitrosoglutathione reductase

…, Y Tang, E Martin, NS Bryan, SP Sanghani - Journal of biological …, 2009 - ASBMB
S-Nitrosoglutathione reductase (GSNOR) is an alcohol dehydrogenase involved in the
regulation of S-nitrosothiols (SNOs) in vivo. Knock-out studies in mice have shown that GSNOR …

Expression of carboxylesterase and lipase genes in rat liver cell-types

…, H Tsukamoto, WF Bosron, SP Sanghani - Biochemical and …, 2008 - Elsevier
Approximately 80% of the body vitamin A is stored in liver stellate cells with in the lipid droplets
as retinyl esters. In low vitamin A status or after liver injury, stellate cells are depleted of …

Identification of microsomal rat liver carboxylesterases and their activity with retinyl palmitate

SP Sanghani, WI Davis, NG Dumaual… - European journal of …, 2002 - Wiley Online Library
Retinyl esters are a major endogenous storage source of vitamin A in vertebrates and their
hydrolysis to retinol is a key step in the regulation of the supply of retinoids to all tissues. …