Hepatocarcinogenesis is a slow process during which genomic changes progressively alter
the hepatocellular phenotype to produce cellular intermediates that evolve into …

The concept that the liver contains epithelial cells that share some of the major properties of
stem cells of the well‐characterized, stem cell‐fed lineages found in bone marrow, intestinal …

Mechanistic target of rapamycin (mTOR) regulates cell growth, metabolism and aging in
response to nutrients, cellular energy stage and growth factors. mTOR is frequently up-regulated …

The variability in the prognosis of individuals with hepatocellular carcinoma (HCC) suggests
that HCC may comprise several distinct biological phenotypes. These phenotypes may …

We analyzed global gene expression patterns of 91 human hepatocellular carcinomas (HCCs)
to define the molecular characteristics of the tumors and to test the prognostic value of the …

Metastasis-related recurrence often occurs in hepatocellular carcinoma (HCC) patients who
receive curative therapies. At present, it is challenging to identify patients with high risk of …

Background & Aims: Although the natural history and pathologic characteristics of human
hepatocellular carcinoma (HCC) are well documented, the molecular pathogenesis of HCC …

Hepatocyte growth factor/scatter factor c-met signaling pathway is of central importance during
development as well as in tumorigenesis. Because homozygous null mice for either hgf/sf …

Growing evidence indicates that microRNAs have a significant role in tumor development
and may constitute robust biomarkers for cancer diagnosis and prognosis. In this study, we …

Aberrant expression of transforming growth factor beta 1 (TGF-beta 1) has been implicated
in a number of disease processes, particularly those involving fibrotic and inflammatory …