Recent studies have demonstrated that addition of a small quantity of dibenzylidene sorbitol
(DBS) to a molten polymer may result in a physical gel if conditions permit the DBS …

… Shepard was supported by a fellowship from the American Foundation for Pharmaceutical
Education. ICollege of Pharmacy, Ohio State University, Columbus, Ohio 43210. 2Department …

It has been suggested in a recent publication that area under the plasma concentration-time
curve (AUC) is dependent on the extent of enterohepatic cycling (EHC), that the ratio of AUC …

Chloroform in swimming pools disinfected with sodium hypochlorite has been demonstrated
to be at elevated levels compared with chlorinated drinking water. Typical chloroform …

Despite the endless rhetoric about the need to demonstrate value in health care delivery and
the debatable sophistry that health care purchasers are truly becoming value oriented, the …

… Shepard and RH Reuning. An equation for the systemic availability of drugs undergoing
simultaneous enterohepatic cycling, first-pass metabolism, and intestinal elimination. Pharm. …

A relationship between systemic availability and its determinants has been derived for a
physiologically realistic model of drug disposition that includes enterohepatic cycling (EHC), …

Following a single dose of a new antihypertensive drug, UP 269-6 (5-methyl-7-propyl-8-[(2'-(1H-tetrazol-5-yl)
biphenyl-4-yl) methyl]-1, 2, 4-triazolo [1, 5-c] pyrimidin-2 (3H)-one, CAS …

A high-performance liquid chromatography method is described for the determination of
digoxin and its metabolites digoxigenin, digoxigenin monodigitoxoside, digoxigenin bis-…

The objective of this research was to determine the stereochemical identity of dihydrodigoxin
(DHD3), a metabolite of digoxin excreted in urine after digoxin administration in man. …