The physiological disposition following intravenous dosing of the separate enantiomers of
indacrinone-14C(I), and of their major metabolite, 4’-hydroxyindacrinone-14C(M), was studied …

The metabolism of a novel polyvalent saluretic agent (6,7-dichloro-2-methyl-1-oxo-2-phenyl-5-indanyloxy)acetic
acid (MK-196) was studied in the chimpanzee. Following oral …

Cerebral angiograms were performed in 14 children with sickle cell disease and clinical
findings of cerebral infarction. The angiogram was normal in four patients. Ten patients had …

Whisker-walled open tubular columns were coated with either manganese(II)chloride or
cobalt(II) chloride. These inorganic salt coated columns were employed to study the interaction …

The physiological disposition of the saluretic-uricosuric agent,(2-cyclopentyl-6, 7-dichloro-2-methyl-1-oxo-5-indanyloxy)
acetic acid (MK-473), was examined in the rat, dog, rhesus …

The physiological disposition of a novel saluretic-uricosuric agent, (6,7-dichloro-2-methyl-1-oxo-2-phenyl-5-indanyloxy)
acetic acid (MK-196) was studied in man and mouse. The drug …

The metabolism of the polyvalent saluretic agent (2-cyclopentyl-6,7-dichloro-2-methyl-1-oxo-5-indanyloxy)acetic
acid was studied in chimpanzee and man. The drug was well absorbed …

MATERIALS AND METHODS After treatment, female Charles River rats weighing 160-210 g
were sacrificed by decapitation; the whole brains were removed and either frozen on dry ice …

A highly specific and sensitive gas chromatographic method for the determination of 6-chloro-2-(1-piperazinyl)pyrazine
(MK-212), a central serotonin-like agent, in biological fluids is …

A specific and quantitative GLC method was developed for the determination of (2‐cyclopentyl‐6,
7‐dichloro‐2‐methyl‐1‐oxo‐5‐indanyloxy)acetic acid, a novel saluretic uricosuric …