Oxysterols are oxygenated derivatives of cholesterol that are intermediates or even end
products in cholesterol excretion pathways. Because of their ability to pass cell membranes and …

We have proposed that 4β‐hydroxycholesterol (4β‐OHC) may be used as an endogenous
marker of CYP3A activity. The cholesterol metabolite 4β‐OHC is formed by CYP3A4. …

There is a clear link between cholesterol turnover and neurodegenerative diseases and
hypercholesterolemia is an established risk factor for Alzheimer's disease (AD). The failure to …

… A comparison between the two groups was performed using Student's t-test for normally
distributed variables, whereas the Mann–Whitney's U-test was used for non-normal distributed …

We have investigated whether side chain-hydroxylated cholesterol species are important for
elimination of cholesterol from the brain. Plasma concentrations of 24-hydroxycholesterol (…

We have previously demonstrated that the brain contains about 80% of the 24S-hydroxycholesterol
in the human body and that there is a net flux of this steroid from the brain into the …

… However, the u se of HPLC-MS utilizing the recently developed atmospheric pressure
chemical ionization technique may prove to be a sensitive and convenient method for oxysterol …

The nuclear oxysterol-receptor paralogues LXRα and LXRβ share a high degree of amino
acid identity and bind endogenous oxysterol ligands with similar affinities. While LXRα has …

Background & Aims: Rifampicin (RIFA) and ursodeoxycholic acid (UDCA) improve symptoms
and biochemical markers of liver injury in cholestatic liver diseases by largely unknown …

24S-hydroxycholesterol is a side-chain oxidized oxysterol formed in the brain that is continuously
crossing the blood-brain barrier to reach the circulation. There may be an opposite flux …