[HTML][HTML] The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats
…, S Roohani, P Welschof, M Kopp, U Gödtel-Armbrust… - Redox biology, 2017 - Elsevier
Hyperglycemia associated with inflammation and oxidative stress is a major cause of vascular
dysfunction and cardiovascular disease in diabetes. Recent data reports that a selective …
dysfunction and cardiovascular disease in diabetes. Recent data reports that a selective …
Carbonyl reductase 1 is a predominant doxorubicin reductase in the human liver
N Kassner, K Huse, HJ Martin, U Gödtel-Armbrust… - Drug Metabolism and …, 2008 - ASPET
A first step in the enzymatic disposition of the antineoplastic drug doxorubicin (DOX) is the
reduction to doxorubicinol (DOX-OL). Because DOX-OL is less antineoplastic but more …
reduction to doxorubicinol (DOX-OL). Because DOX-OL is less antineoplastic but more …
Reversal of endothelial nitric oxide synthase uncoupling and up-regulation of endothelial nitric oxide synthase expression lowers blood pressure in hypertensive rats
…, M August, I Brausch, U Gödtel-Armbrust… - Journal of the American …, 2006 - jacc.org
Objectives : We sought to examine the hypothesis that a pharmacologic up-regulation of
endothelial nitric oxide synthase (eNOS) combined with a reversal of eNOS uncoupling …
endothelial nitric oxide synthase (eNOS) combined with a reversal of eNOS uncoupling …
[HTML][HTML] Dexrazoxane may prevent doxorubicin-induced DNA damage via depleting both topoisomerase II isoforms
…, C Jendrny, A Nemecek, M Vincetic, U Gödtel-Armbrust… - BMC cancer, 2014 - Springer
Background The bisdioxopiperazine dexrazoxane (DRZ) prevents anthracycline-induced
heart failure, but its clinical use is limited by uncertain cardioprotective mechanism and by …
heart failure, but its clinical use is limited by uncertain cardioprotective mechanism and by …
Dominant Contribution of P450 3A4 to the Hepatic Carcinogenic Activation of Aflatoxin B1
…, I Meineke, U Gödtel-Armbrust… - Chemical research in …, 2006 - ACS Publications
The hepatic carcinogen aflatoxin B 1 (AFB 1 ) is metabolized in the liver by at least four
different P450s, all of which exhibit large interindividual differences in the expression levels. …
different P450s, all of which exhibit large interindividual differences in the expression levels. …
Association of genetic polymorphism in ABCC2 with hepatic multidrug resistance-associated protein 2 expression and pravastatin pharmacokinetics
…, MK Pasanen, U Gödtel-Armbrust… - Pharmacogenetics …, 2006 - journals.lww.com
Objective Our aim was to investigate possible effects of sequence variations in ABCC2,
encoding the multidrug resistance-associated protein 2 (MRP2), on the pharmacokinetics of the …
encoding the multidrug resistance-associated protein 2 (MRP2), on the pharmacokinetics of the …
Association of NADPH oxidase polymorphisms with anthracycline-induced cardiotoxicity in the RICOVER-60 trial of patients with aggressive CD20+ B-cell lymphoma
…, M Ziepert, M Kreuz, U Gödtel-Armbrust… - …, 2015 - Future Medicine
Aim: To identify gene variants responsible for anthracycline-induced cardiotoxicity. Patients
& methods: Polymorphisms of the NADPH oxidase subunits and of the anthracycline …
& methods: Polymorphisms of the NADPH oxidase subunits and of the anthracycline …
The catalytic topoisomerase II inhibitor dexrazoxane induces DNA breaks, ATF 3 and the DNA damage response in cancer cells
…, A Nemecek, U Gödtel‐Armbrust… - British journal of …, 2015 - Wiley Online Library
Background and Purpose The catalytic topoisomerase II inhibitor dexrazoxane has been
associated not only with improved cancer patient survival but also with secondary malignancies …
associated not only with improved cancer patient survival but also with secondary malignancies …
Inducible NO synthase II and neuronal NO synthase I are constitutively expressed in different structures of guinea pig skeletal muscle: implications for contractile …
I Gath, EI Closs, U Gödtel‐Armbrust… - The FASEB …, 1996 - Wiley Online Library
The expression of NOS isoforms was studied in guinea pig skeletal muscle at the mRNA
and protein level, and the effect of NO on contractile response was examined. Ribonuclease …
and protein level, and the effect of NO on contractile response was examined. Ribonuclease …
6‐mercaptopurine and 9‐(2‐phosphonyl‐methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4
…, S Mehralivand, D Strand, U Gödtel‐Armbrust… - Human …, 2008 - Wiley Online Library
Multiple drug resistance protein 4 (MRP4, ABCC4) belongs to the C subfamily of the ATP‐binding
cassette (ABC) transporter superfamily and participates in the transport of diverse …
cassette (ABC) transporter superfamily and participates in the transport of diverse …