The protective effect of metallothionein on the toxicity of various metals in rat primary hepatocyte culture
J Liu, WC Kershaw, CD Klaassen - Toxicology and applied pharmacology, 1991 - Elsevier
Metallothionein (MT), a low-molecular-weight, cysteine-rich, metal-binding protein, has been
implicated in the detoxification of Cd. However, whether MT protects against the cellular …
implicated in the detoxification of Cd. However, whether MT protects against the cellular …
In vitro and in vivo studies on the degradation of metallothionein.
…, LD Lehman-McKeeman, WC Kershaw - Environmental …, 1994 - ehp.niehs.nih.gov
Degradation of metallothionein (MT) from rat liver was examined. Degradation of apo-MT by
liver homogenate was greater than that by cytosol. At pH 5.5, degradation by homogenate …
liver homogenate was greater than that by cytosol. At pH 5.5, degradation by homogenate …
Rat primary hepatocyte cultures are a good model for examining metallothionein-induced tolerance to cadmium toxicity
J Liu, WC Kershaw, CD Klaassen - In vitro cellular & developmental …, 1990 - Springer
The effect of Zn-induced metallothionein (MT) on the toxicity, uptake, and subcellular
distribution of cadmium (Cd) was examined in rat primary hepatocyte cultures and compared to …
distribution of cadmium (Cd) was examined in rat primary hepatocyte cultures and compared to …
Cadmium-induced hepatic endothelial cell injury in inbred strains of mice
J Liu, WC Kershaw, YP Liu, CD Klaassen - Toxicology, 1992 - Elsevier
Susceptibility to cadmium (Cd) hepatotoxicity differs among inbred strains of mice. For
example, C3H/HeJ mice are sensitive to Cd-induced hepatotoxicity, whereas DBA/2J micre are …
example, C3H/HeJ mice are sensitive to Cd-induced hepatotoxicity, whereas DBA/2J micre are …
Degradation and metal composition of hepatic isometallothioneins in rats
WC Kershaw, CD Klaassen - Toxicology and Applied Pharmacology, 1992 - Elsevier
Recently, our laboratory demonstrated that metallothionein-1 (MT-1) is degraded faster than
metallothionein-2 (MT-2) in liver of Zn-treated adult rats; however, it is not clear whether this …
metallothionein-2 (MT-2) in liver of Zn-treated adult rats; however, it is not clear whether this …
Protective effects of zinc on cultured rat primary hepatocytes to metals with low affinity for metallothionein
J Liu, WC Kershaw, CD Klaassen - Journal of Toxicology and …, 1992 - Taylor & Francis
The purpose of this study was to determine if Zn pretreatment could protect rat primary
hepatocyte cultures from the cytotoxicity of five metals that have little or no affinity for …
hepatocyte cultures from the cytotoxicity of five metals that have little or no affinity for …
Ethanol decreases cadmium hepatotoxicity in rats: possible role of hepatic metallothionein induction
WC Kershaw, T Iga, CD Klaassen - Toxicology and applied pharmacology, 1990 - Elsevier
The present investigation examines the possibility that Cd and ethanol have a significant
toxicological interaction. This examination was warranted as exposure to either chemical is …
toxicological interaction. This examination was warranted as exposure to either chemical is …
Hepatic isometallothioneins in mice: induction in adults and postnatal ontogeny
WC Kershaw, LD Lehman-McKeeman… - Toxicology and applied …, 1990 - Elsevier
The purpose of this study was to quantitate hepatic metallothionein-I (MT-I) and metallothionein-II
(MT-II) in adult mice pretreated with various dosages of selected inorganic and organic …
(MT-II) in adult mice pretreated with various dosages of selected inorganic and organic …
Cadmium-induced elevation of hepatic isometallothionein concentrations in inbred strains of mice
WC Kershaw, CD Klaassen - Chemico-biological interactions, 1991 - Elsevier
Susceptibility to Cd toxicity differs among inbred strains of mice. For example, C3H/He mice
are sensitive to Cd-induced hepatotoxicity while DBA/2 mice are resistant. Metallothionein (…
are sensitive to Cd-induced hepatotoxicity while DBA/2 mice are resistant. Metallothionein (…
Cd‐metallothionein nephrotoxicity in inbred strains of mice
LE Sendelbach, WC Kershaw, F Cuppage… - Journal of Toxicology …, 1992 - Taylor & Francis
Genetic differences in the acute hepatic and testicular toxicity of Cd occur among different
strains of mice. However, it is not known whether genetic variation to the renal damage caused …
strains of mice. However, it is not known whether genetic variation to the renal damage caused …