In addition to mass accuracy, the ability of a mass spectrometer to faithfully measure the
isotopic distribution of an ion, defined as spectral accuracy, is also important. Although time-of-…

Tigecycline, a novel, first-in-class glycylcycline antibiotic, has been approved for the
treatment of complicated intra-abdominal infections and complicated skin and skin structure …

Metabolite identification studies remain an integral part of pre‐clinical and clinical drug
development programs. Analysis of biological matrices, such as plasma, urine, feces and bile, …

Bazedoxifene is a selective estrogen receptor modulator under development for the prevention
and treatment of osteoporosis. The disposition of [ 14 C]bazedoxifene was determined in …

Prazosin (2-[4-(2-furanoyl)-piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline) is an
antihypertensive agent that was introduced to the market in 1976. It has since established an …

For reprint orders, please contact reprints@ future-science. com principles of Good Laboratory
Practice (GLP) with any aspects of method validation not performed according to GLP …

An open letter written by the Global CRO Council for Bioanalysis (GCC) describing the GCC
survey results on stability data from co-administered and co-formulated drugs was sent to …

Methylnaltrexone (MNTX), a selective μ-opioid receptor antagonist, functions as a peripherally
acting receptor antagonist in tissues of the gastrointestinal tract. This report describes the …

Bazedoxifene (BZA) acetate, a novel estrogen receptor modulator being developed for the
prevention and treatment of postmenopausal osteoporosis, undergoes extensive metabolism …

Background: This series of experiments was conducted to describe the metabolic profile of
the serotoninnorepinephrine reuptake inhibitor desvenlafaxine (administered as …