[HTML][HTML] Cellular irinotecan resistance in colorectal cancer and overcoming irinotecan refractoriness through various combination trials including DNA …

…, T Miura, J Terashima, W Habano - Cancer Drug …, 2021 - ncbi.nlm.nih.gov
… Shogo Ozawa, corresponding author Toshitaka Miura, Jun Terashima, and Wataru
Habano … to the literature search on general epigenetic regulatory mechanisms: Habano W

Microsatellite instability in the mitochondrial DNA of colorectal carcinomas: evidence for mismatch repair systems in mitochondrial genome

W Habano, S Nakamura, T Sugai - Oncogene, 1998 - nature.com
… Therefore, in the present study, we applied a crypt isolation technique (Habano et al., in
press; Habano et al., 1996; Nakamura et al., 1993, 1994; Yoshida et al., 1996) that allows the …

Analysis of molecular alterations in left-and right-sided colorectal carcinomas reveals distinct pathways of carcinogenesis: proposal for new molecular profile of …

T Sugai, W Habano, YF Jiao, M Tsukahara… - The Journal of Molecular …, 2006 - Elsevier
To clarify distinct genetic profiles of colorectal cancers based on tumor location (left- and
right-sided), we evaluated the status of loss of heterozygosity (LOH), CpG islands methylation …

Decreased expression of cytochromes P450 1A2, 2E1, and 3A4 and drug transporters Na+-taurocholate-cotransporting polypeptide, organic cation transporter 1, and …

…, A Miyajima, S Ishida, M Sunouchi, W Habano… - Drug Metabolism and …, 2008 - ASPET
Patients with chronic hepatitis C viral infection underwent liver biopsies and laboratory
studies for evaluation and to determine subsequent treatment. Changes in status of drug …

[HTML][HTML] Aryl hydrocarbon receptor as a DNA methylation reader in the stress response pathway

W Habano, T Miura, J Terashima, S Ozawa - Toxicology, 2022 - Elsevier
The aryl hydrocarbon receptor (AhR) mediates various cellular responses upon exposure to
exogenous and endogenous stress factors. In these responses, AhR plays a dual role as a …

Microsatellite instability and mutation of mitochondrial and nuclear DNA in gastric carcinoma

W Habano, T Sugai, SI Nakamura, N Uesugi… - Gastroenterology, 2000 - Elsevier
Background & Aims: Microsatellite instability (MSI) in mitochondrial DNA (mtDNA) is
observed in some colorectal carcinomas. We attempted to determine if mitochondrial MSI (mtMSI) …

Correlation between C677T MTHFR gene polymorphism, plasma homocysteine levels and the incidence of CAD

K Nakai, C Itoh, K Nakai, W Habano… - American Journal of …, 2001 - Springer
The lesions of coronary atherosclerosis represent the result of a complex, multicellular,
inflammatoryhealing response in the coronary arterial wall. In vivo and in vitro cellular and …

Mitochondrial gene mutation, but not large‐scale deletion, is a feature of colorectal carcinomas with mitochondrial microsatellite instability

W Habano, T Sugai, T Yoshida… - International journal of …, 1999 - Wiley Online Library
We have shown that microsatellite instability (MSI) occurs in mitochondrial DNA (mtDNA) of
colorectal carcinomas. To determine whether such mitochondrial microsatellite instability (…

Reduced expression and loss of heterozygosity of the SDHD gene in colorectal and gastric cancer

W Habano, T Sugai, SI Nakamura… - Oncology …, 2003 - spandidos-publications.com
Mitochondrial DNA (mtDNA) mutations occur in a variety of human cancers, suggesting a
possible role for mitochondrial respiratory functions in tumorigenesis. Recent studies have …

[HTML][HTML] Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells

W Habano, T Gamo, J Terashima, T Sugai, K Otsuka… - BMC cancer, 2011 - Springer
Background Pregnane X receptor (PXR) is a key transcription factor that regulates drug
metabolizing enzymes such as cytochrome P450 (CYP) 3A4, and plays important roles in …