Role of carnitine esters in brain neuropathology

A Virmani, Z Binienda - Molecular aspects of medicine, 2004 - Elsevier
l-Carnitine (LC) is a naturally occurring quaternary ammonium compound endogenous in all
mammalian species and is a vital cofactor for the mitochondrial oxidation of fatty acids. Fatty …

Food, nutrigenomics, and neurodegeneration—neuroprotection by what you eat!

A Virmani, L Pinto, Z Binienda, S Ali - Molecular neurobiology, 2013 - Springer
Diet in human health is no longer simple nutrition, but in light of recent research, especially
nutrigenomics, it is linked via evolution and genetics to cell health status capable of …

[HTML][HTML] Molecular aspects of dopaminergic neurodegeneration: gene-environment interaction in parkin dysfunction

SF Ali, ZK Binienda, SZ Imam - International journal of environmental …, 2011 - mdpi.com
Parkinson’s disease (PD) is a common neurodegenerative movement disorder that is
characterized pathologically by a progressive loss of midbrain dopaminergic neurons and by …

Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of l‐carnitine

…, J Villeda‐Hernández, Z Binienda… - Journal of …, 2008 - Wiley Online Library
Excitotoxicity and disrupted energy metabolism are major events leading to nerve cell death
in neurodegenerative disorders. These cooperative pathways share one common aspect: …

Iron oxide nanoparticles induce dopaminergic damage: in vitro pathways and in vivo imaging reveals mechanism of neuronal damage

…, B Gough, MG Paule, SF Ali, ZK Binienda - Molecular …, 2015 - Springer
Various iron-oxide nanoparticles have been in use for a long time as therapeutic and
imaging agents and for supplemental delivery in cases of iron-deficiency. While all of these …

[HTML][HTML] Neuroprotective efficacy of a new brain-penetrating C-Abl inhibitor in a murine Parkinson's disease model

SZ Imam, W Trickler, S Kimura, ZK Binienda… - PLoS one, 2013 - journals.plos.org
Experimental evidence suggests that oxidative and nitrative mechanisms account for much of
the dopaminergic neuronal injury in Parkinson’s disease (PD). The ubiquitously expressed …

Neuroprotective role of L-carnitine in the 3-nitropropionic acid induced neurotoxicity

ZK Binienda, SF Ali - Toxicology letters, 2001 - Elsevier
… The resulting homogenate was centrifuged at 1600×g for 12 min in a Hermle model Z
360K centrifuge. The supernatant was decanted and centrifuged at 20 000×g for 12 min in an …

Acetyl-L-carnitine provides effective in vivo neuroprotection over 3, 4-methylenedioximethamphetamine-induced mitochondrial neurotoxicity in the adolescent rat brain

E Alves, Z Binienda, F Carvalho, CJ Alves… - Neuroscience, 2009 - Elsevier
3,4-Methylenedioximethamphetamine (MDMA, ecstasy) is a worldwide abused stimulant
drug, with persistent neurotoxic effects and high prevalence among adolescents. The massive …

Introducing Black-Gold II, a highly soluble gold phosphate complex with several unique advantages for the histochemical localization of myelin

L Schmued, J Bowyer, M Cozart, D Heard, Z Binienda… - Brain research, 2008 - Elsevier
A novel gold phosphate complex called Black-Gold II with improved myelin staining properties
has been developed. It differs from its predecessor, Black-Gold, in that it is highly water …

The protective role of l‐carnitine against neurotoxicity evoked by drug of abuse, methamphetamine, could be related to mitochondrial dysfunction

…, F Gaetani, S Imam, Z Binienda… - Annals of the New …, 2002 - Wiley Online Library
There is growing evidence that suggests that brain injury after amphetamine and
methamphetamine (METH) administration is due to an increase in free radical formation and …