[HTML][HTML] Pharmacokinetic herb-drug interactions (part 2): drug interactions involving popular botanical dietary supplements and their clinical relevance

BJ Gurley, EK Fifer, Z Gardner - Planta medica, 2012 - thieme-connect.com
In Part 2 of this review, a critical examination of the pertinent scientific literature is
undertaken in order to assess the interaction risk that popular dietary supplements may pose …

Herbal medicines in the treatment of psychiatric disorders: a systematic review

J Sarris - Phytotherapy Research, 2007 - Wiley Online Library
This paper reports a critical review of 27 herbal medicines and formulas in treating a broad
range of psychiatric disorders (in addition to anxiety and depression), including obsessive …

[HTML][HTML] Hepatotoxicity of herbal supplements mediated by modulation of cytochrome P450

CT Brewer, T Chen - International Journal of Molecular Sciences, 2017 - mdpi.com
Herbal supplements are a significant source of drug-drug interactions (DDIs), herb-drug
interactions, and hepatotoxicity. Cytochrome P450 (CYP450) enzymes metabolize a large …

Activation of CAR and PXR by dietary, environmental and occupational chemicals alters drug metabolism, intermediary metabolism, and cell proliferation

JP Hernandez, LC Mota… - Current …, 2009 - ingentaconnect.com
The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are
activated by a variety of endogenous and exogenous ligands, such as steroid hormones …

Kava and St. John's Wort: current evidence for use in mood and anxiety disorders

J Sarris, DJ Kavanagh - The Journal of Alternative and …, 2009 - liebertpub.com
Background: Mood and anxiety disorders pose significant health burdens on the community.
Kava and St. John's wort (SJW) are the most commonly used herbal medicines in the …

Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: an update

SF Zhou, CC Xue, XQ Yu, G Wang - Current drug metabolism, 2007 - ingentaconnect.com
In recent years, there has been a globally increasing application of herbal medicines and
dietary supplements to treat various chronic diseases and to promote health. However, there …

Activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by herbal medicines

TKH Chang - The AAPS journal, 2009 - Springer
Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are transcription
factors that control the expression of a broad array of genes involved not only in transcellular …

Herbal bioactivation, molecular targets and the toxicity relevance

XW Chen, ES Serag, KB Sneed, SF Zhou - Chemico-biological interactions, 2011 - Elsevier
There have been increasing reports on the adverse reactions associated with herbal
consumption. For many of these adverse reactions, the underlying biochemical mechanisms …

Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR)

TKH Chang, DJ Waxman - Drug metabolism reviews, 2006 - Taylor & Francis
Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are members of the
nuclear receptor superfamily. These transcription factors are predominantly expressed in the …

Pregnane X receptor and natural products: beyond drug–drug interactions

JL Staudinger, X Ding, K Lichti - Expert opinion on drug metabolism …, 2006 - Taylor & Francis
The pregnane X receptor (PXR, NR1I2) is a member of the nuclear receptor superfamily that
is activated by a myriad of compounds and natural products in clinical use. Activation of PXR …