Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases
Milk thistle (MT; Silybum marianum), a member of the Asteraceae family, is a therapeutic
herb with a 2,000‐year history of use. MT fruits contain a mixture of flavonolignans …
herb with a 2,000‐year history of use. MT fruits contain a mixture of flavonolignans …
[HTML][HTML] The mechanisms of pharmacokinetic food-drug interactions–A perspective from the UNGAP group
The simultaneous intake of food and drugs can have a strong impact on drug release,
absorption, distribution, metabolism and/or elimination and consequently, on the efficacy …
absorption, distribution, metabolism and/or elimination and consequently, on the efficacy …
[HTML][HTML] Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaernt.)—Chemistry, Bioavailability, and Metabolism
M Bijak - Molecules, 2017 - mdpi.com
Milk thistle (Silybum marianum) is a medicinal plant that has been used for thousands of
years as a remedy for a variety of ailments. The main component of S. marianum fruit extract …
years as a remedy for a variety of ailments. The main component of S. marianum fruit extract …
Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios
JA Williams, R Hyland, BC Jones, DA Smith… - Drug Metabolism and …, 2004 - ASPET
Glucuronidation is a listed clearance mechanism for 1 in 10 of the top 200 prescribed drugs.
The objective of this article is to encourage those studying ligand interactions with UDP …
The objective of this article is to encourage those studying ligand interactions with UDP …
Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine
SC Pradhan, C Girish - Indian journal of medical research, 2006 - journals.lww.com
Silymarin, a flavonolignan from′ milk thistle′(Silybum marianum) plant is used almost
exclusively for hepatoprotection and amounts to 180 million US dollars business in Germany …
exclusively for hepatoprotection and amounts to 180 million US dollars business in Germany …
Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4
SF Zhou - Current drug metabolism, 2008 - ingentaconnect.com
Human cytochrome P450 (CYP) 3A4 is the most abundant hepatic and intestinal phase I
enzyme that metabolizes approximately 50% marketed drugs. The crystal structure of bound …
enzyme that metabolizes approximately 50% marketed drugs. The crystal structure of bound …
Herb-drug interactions: a literature review
Herbs are often administered in combination with therapeutic drugs, raising the potential of
herb-drug interactions. An extensive review of the literature identified reported herb-drug …
herb-drug interactions. An extensive review of the literature identified reported herb-drug …
[HTML][HTML] Silybin and the liver: from basic research to clinical practice
C Loguercio, D Festi - World journal of gastroenterology: WJG, 2011 - ncbi.nlm.nih.gov
Herbal products are increasingly used, mainly in chronic liver disease. Extracts of milk
thistle, Silymarin and silybin, are the most prescribed natural compounds, with different …
thistle, Silymarin and silybin, are the most prescribed natural compounds, with different …
[BOOK][B] Natural products from plants
LJ Cseke, A Kirakosyan, PB Kaufman, S Warber… - 2016 - api.taylorfrancis.com
2008 NOMINEE The Council on Botanical and Horticultural Libraries Annual Award for a
Significant Work in Botanical or Horticultural Literature From medicinal, industrial, and …
Significant Work in Botanical or Horticultural Literature From medicinal, industrial, and …
[HTML][HTML] Traditional use and safety of herbal medicines
DL Moreira, SS Teixeira, MHD Monteiro… - Revista Brasileira de …, 2014 - Elsevier
Abstract In the European Union, traditional herbal medicines that are regarded as
“acceptably safe, albeit not having a recognized level of efficacy” fit into a special category of …
“acceptably safe, albeit not having a recognized level of efficacy” fit into a special category of …