This report summarizes a symposium sponsored by the American Society for Pharmacology
and Experimental Therapeutics at Experimental Biology held April 20-24 in Boston, MA …

This article features selected findings from the senior author and colleagues dating back to
1978 and covering approximately three-fourths of the 60 years since the discovery of …

The protein database has> 450 entries with P450 in the title and of these there are
approximately 54 unique structures. Although this sample of unique structures is small …

Cytochrome P450 isoenzymes are pivotal in drug clearance. Part 1 of this two-part review,
published in the October issue of Drug Discovery Today, described the active site …

It is an honor to be the recipient of the 2002 Bernard B. Brodie Award in Drug Metabolism
from the American Society for Pharmacology and Experimental Therapeutics. In receiving …

Microsomal P450-mediated monooxygenase activity supported by NADPH requires an
interaction between flavoprotein NADPH-cytochrome P450 reductase and cytochrome …

Cytochrome P450 (P450) enzymes are important in the metabolism of drugs, steroids, fat-
soluble vitamins, carcinogens, pesticides, and many other types of chemicals. Their catalytic …

Cytochromes P450 (P450) are membrane-bound enzymes that catalyze the
monooxygenation of a diverse array of xenobiotic and endogenous compounds. The P450s …

This symposium summary, sponsored by the ASPET, was held at Experimental Biology
2015 on March 29, 2015, in Boston, Massachusetts. The symposium focused on: 1) the …

This article reviews work from the author dating back to 1978 and focuses on the structural
basis of cytochrome P450 (P450) function using available contemporary techniques. Early …