Abstract
1. In rats, the acute oral toxicity of methoxychlor is low.
2. In short-term feeding tests, ten male and ten female rats were maintained for about 45 days on diets containing 0 (a control group), 0.01, 0.1 and 3 per cent methoxychlor, respectively. The addition of 0.1 per cent produced a small but detectable growth depression. Practically no growth occurred on diets containing 3 per cent methoxychior and eight of ten rats (both male and female) died.
3. A paired-feeding test was conducted in which ten male and ten female rats of the experimental group were maintained on a diet containing 1 per cent methoxychlor. Voluntary food refusal was shown to be responsible for most of the growth retardation. The testes were extraordinarily small in the experimental rats.
Footnotes
- Received February 6, 1950.