Supplemental Data
Files in this Data Supplement:
- Supplemental Data -
Scheme 1 - Synthesis of 14CAZD3839 hemifumarate from U-14C-1,3-dibromobenzene...
Scheme 2 - Synthesis of 3H-(1S)-4-fluoro-1-(pyridin-4-yl)-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine prepared from a brominated compound...
Supplemental Figure 1 - 3H-NMR of 75 MBq 3H-(S)- 1-pyridin-4-yl-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine at 140 muM in CD3OD
Supplemental Figure 2 - Metabolic profiling of AZD3839 in microsomes
Supplemental Table 1 - Summary of detected metabolites in excreta expressed as average fractions of the total administered dose of 3H-(S)-25 to male Sprague Dawley rats (30 mumol/kg, 50 MBq/kg)
Supplemental Table 2 - Summary of detected metabolites in excreta expressed as average fractions of the total administered dose of 14C-AZD3839 to male Han Wistar rats (58 mumol/kg, 9.25 MBq/kg).