Data Supplement
Files in this Data Supplement:
- Data Supplement -
Supplementary Figure S1 - Molecular structures of the fourteen compounds tested in the present study
Supplementary Figure S2 - Effects of fourteen protein kinase inhibitors on amodiaquine Ndeethylation and midazolam 1?-hydroxylation
Supplementary Table S1 - Parameters used in the static predictions of drug-drug interaction potential based on in vitro inhibition data
Supplementary Table S2 - Prediction of the maximal effect of direct and mechanism-based inhibition on the pharmacokinetics of CYP2C8 and CYP3A substrates by five protein kinase inhibitors
Supplementary Table S3 - Fourteen protein kinase inhibitors and their inhibitory effects on CYP2C8 activity in HLM incubations as reported in the literature and in the present study
Supplementary Table S4 - Fourteen protein kinase inhibitors and their inhibitory effects on CYP3A activity in HLM incubations as reported in the literature and in the present study
Supplementary Table S5 - Examples of CYP2C8- and CYP3A-mediated interactions with the protein kinase inhibitors tested in the present study as perpetrator drugs
Supplementary Table S6 - Examples of CYP3A-mediated interactions with the protein kinase inhibitors tested in the present study as victim drugs