Data Supplement
Files in this Data Supplement:
- Supplemental Figures -
Supplemental Figure 1 - Analysis of native heme
Supplemental Figure 2 - LC-ESI-MS analysis of CYP3A4 incubated with iodoacetamide
Supplemental Figure 3 - Analysis of SCH 66712 metabolites formed by CYP3A4
Supplemental Figure 4 - Identification of m/z 355 isomeric products
Supplemental Figure 5 - Analysis of EMTPP metabolites formed by CYP3A4
Supplemental Figure 6 - Molecular docking of inactivators in the active site of CYP3A4 (3NXU)
Supplemental Table I - Predicted sites of metabolism on SCH 66712 and EMTPP by CYP2D6 and CYP3A4 and correlation with observed metabolites in mass spectrometry