In Vitro Metabolism of Montelukast by Cytochrome P450s (CYPs) and UDP-Glucuronosyltransferases (UGTs)

Data Supplement

Files in this Data Supplement:

• Supplemental Data -

  Supplemental Table 1 - Correlation of formation rates of montelukast 1,2 diol, 21(R)-OH montelukast, 21(S)-OH montelukast and 25-OH montelukast from montelukast (1 mu-M) metabolism with the activities of different P450 isoforms and total P450 contents in 14 HLMs

  Supplemental Figure 1 - The formation rate of montelukast 1,2 diol, 21(R)-OH montelukast, 21(S)-OH montelukast and 25-OH montelukast in a panel of 14 characterized HLMs

  Supplemental Figure 2 - Formation rate of montelukast sulfoxide in a panel of 10 recombinant human CYP P450s

  Supplemental Figure 3 - Inhibition of montelukast glucuronidation to montelukast acyl-beta-D glucuronide and M-glucuronide by gemfibrozil in HLM