Data Supplement
Files in this Data Supplement:
- Supplemental Data -
Supplemental Table 1 - List of human P450 oligonucleotide premade QuantiTect primer assays from Qiagen
Supplemental Table 2 - Significant proteins in the global subset
Supplemental Table 3 - Significant proteins in the ABPP subset
Supplemental Figure 1 - Comparison of P450 protein abundance to ABPP measured functional activity - Supplemental Dataset Descriptions
-
Dataset 1 - Sample metadata. Availability of sample information is quite disparate
Dataset 2 - Global proteomics statistics values as determined by approaches described in the Materials and Methods section of the manuscript
Dataset 3 - Activity-based protein profiling proteomics statistics values as determined by approaches described in the Materials and Methods section of the manuscript
Dataset 4 - Transformed qRT-PCR values showing the fold-change of expression to an internal housekeeping gene, GAPDH. Data corresponds with Figure 2 in the manuscript. Gest. day = gestational day
Dataset 5 - Raw qRT-PCR values
Dataset 6 - Transformed qRT-PCR values showing the fold-change of expression to an internal housekeeping gene, beta-actin. Gest. day = gestational day
Dataset 7 - Global proteomics accurate mass and time (AMT) tag abundance values for P450 protein expression. Missing values are imputed as one-half the minimum measured value. TM - trimester, FL - fetal, AL - adult
Dataset 8 - Individual peptide AMT tag values for P450 protein expression. TM - trimester, FL - fetal, AL - adult
Dataset 9 - AMT tag abundance values for P450 functional activity as determined by activitybased protein profiling (ABPP). Missing values are imputed as one-half the minimum measured value. TM - trimester, FL - fetal, AL - adult
Dataset 10 - Individual peptide AMT tag values for ABPP determined abundance. TM - trimester, FL - fetal, AL - adult