Data Supplement
Files in this Data Supplement:
- Supplemental Data -
Supplemental Methods
Supplemental Table 1 - Comparison of area under the systemic drug concentration-time curve from time zero to infinity (AUC0-∞) and area under the systemic drug concentration-time curve from time zero to last measured concentration (AUC last)
Supplemental Figure 1 - Sensitivity analysis on various model input parameters and their effect on predicted oral clearance (CL/F) and area under the curve (AUC0-∞) of R and S carvedilol in pediatric chronic heart failure patients
Supplemental Figure 2 - Predicted R and S-carvedilol systemic concentration vs. time profiles from the sensitivity analysis by changing the values of input parameters in 10 runs
Supplemental Figure 3 - Observed vs. predicted concentrations plots in healthy adults after intravenous (A, B), and oral (C, D) racemic carvedilol application, and in chronic heart failure patients after oral application racemic carvedilol (E, F)
Supplemental Figure 4 - Model predictions in the entire pediatric age range n=15 (0.12 to 17.8 year) including the young adult n=1 (19.3 year) after administering 0.09 mg/kg racemic carvedilol, (A, B) systemic concentration-time plots...
Supplemental Figure 5 - Observed vs. predicted concentrations plots in pediatric CHF patients after administering 0.09 mg/kg racemic carvedilol (a, b).