Data Supplement
Files in this Data Supplement:
- Supplemental Data -
Supplemental Table 1 - Population PK parameter estimates for the final IV and oral combined model of the P045 data
Supplemental Table 2 - The systemic disposition of odanacatib appears to be linear, as assessed by comparison of 13C -labeled odanacatib PK resulting from 1 mg IV administration when co-administered with varying doses of unlabeled odanacatib
Supplemental Table 3 - 13C -isotopic labeling does not alter the pharmacokinetics of IV-administered odanacatib, as assessed following 1 mg IV unlabeled and 13C -labeled doses
Supplemental Figure 1 - Individual concentration-time plots for subjects who received 1 mg IV 13C-odanacatib and 50 mg oral unlabeled odanacatib with a high-fat meal: examples of concordance between fluctuations in IV and oral profiles (panel titles indicate AN)
Supplemental Figure 2 - Comparison of the absorption profile for different doses and fed states after either model-independent deconvolution (solid) or using a Hill function (dashed)
Supplemental Figure 3 - Visual predictive check for the final IV/oral combined model
- Supplemental Data -
Protocol 045-00