Data Supplement
Files in this Data Supplement:
- Supplemental Data -
Differential equations (mass balance equations) for the PK models in this work
Supplemental Table 1 - Demographic information
Supplemental Table 2 - Fitting statistics of pharmacokinetic models to experimental data
Supplemental Table 3 - Parameters derived from fitting of the PK/PD model to the data both in non-obese and morbidly obese patients
Supplemental Figure 1 - Approval letter from the Research Ethics Committee
Supplemental Figure 2 - Representative HPLC chromatogram analysis of propofol and SNX-2112 (the internal standard) in human plasma
Supplemental Figure 3 - Observed vs predicted plots generated from population fitting of two-compartment model to pharmacokinetic data of control...
Supplemental Figure 4 - Plots of observed (plus sign), population predicted (red line) and individual predicted (green line) BIS values vs. time generated from fitting the PK/PD model to data of control patiens (n=6)
Supplemental Figure 5 - Plots of observed (plus sign), population predicted (red line) and individual predicted (green line) BIS values vs. time generated from fitting the Pk?PD model to data of MO patients receiving propofol based on TBW (n=12)
Supplemental Figure 6 - Plots observed (plus sign), population predicted (red line) and individual predicted (green line) BIS values vs. time generated from fitting the PK/PD model to data of MO patients receiving propofol based on LBW (n=11)