Data Supplement
Files in this Data Supplement:
- Supplemental Data -
Supplemental Table 1 - Results of an MBI reversibility assay of CYP3A involving human liver microsomes with fluoroquinolone compounds
Supplemental Figure 1 - Multiple time- and concentration-dependent inhibition in recombinant CYP3A4 Supersomes by compounds 1 (A and B) and 6 (C and D)
Supplemental Table 2 - KI and kinact of compounds 1 and 6 obtained from multiple time- and concentration inhibition in recombinant CYP3A4 Supersomes
Supplemental Table 3 - Mass spectrometric data on fluoroquinolone compounds from accurate mass analysis and hydrogen-deuterium exchange measurement
Supplemental Figure 2 - Extracted ion chromatograms of the metabolites in the samples after 30-min incubation of compound 2 with recombinant CYP3A4 Supersomes in the presence of NADPH...
Supplemental Figure 3 - Extracted ion chromatograms of the metabolites in the samples after 30-min incubation of compound 5 with recombinant CYP3A4 Supersomes in the presence of NADPH...
Supplemental Figure 4 - Extracted ion chromatograms of the metabolites in the samples after 30-min incubation of compound 8 with recombinant CYP3A4 Supersomes in the presence of NADPH...
Supplemental Figure 5 - PDB code 2V0M for compound 6
Supplemental Figure 6 - PDB code 4I4G for the nitroso metabolite of compound 6