Data Supplement
Files in this Data Supplement:
- Supplemental Data -
Supplemental Table 1 - Donor information for hepatocytes used for HepatoPac cultures
Supplemental Table 2 - Summary of tryptic peptides and their selected reaction-monitoring parameters used for LC-MS/MS protein measurements
Supplemental Table 3 - CYP3A4 stability data (mRNA, protein expression, and enzymatic activity) for four HepatoPac donors for Days 10-13 of SILAC culture
Supplemental Table 4 - Calculated t1/2 (h) and kdeg (h-1) values from individual donors for CYP3
Supplemental Figure 1 - Representative SRM chromatograms showing CYP3A4 peptide, SLLSPTFTSGK, for one HepatoPac donor over Days 10-13 with SILAC