Data Supplement
- Supplemental Data -
Supplemental Table 1 - CYP inhibition assay conditions
Supplemental Table 2 - UGT inhibition assay conditions
Supplemental Table 3 - CYP time-dependent inhibition assay conditions
Supplemental Table 4 - CYP probe sets used in induction studies
Supplemental Table 5 - Paritaprevir PBPK model input parameters in Simcyp V14.1
Supplemental Table 6 - Ritonavir PBPK model input parameters in Simcyp V14.1
Supplemental Table 7 - Dasabuvir PBPK model input parameters in Simcyp V14.1
Supplemental Table 8 - In vitro CYP, UGT, and transporters inhibition potency of paritaprevir, ritonavir, ombitasvir, dasabuvir, and M1
Supplemental Table 9 - In vitro CYP induction by paritaprevir, ritonavir, ombitasvir, dasabuvir, and M1
Supplemental Figure 1 - PBPK Model Verification of Paritaprevir Simulated PK profile
Supplemental Figure 2 - PBPK Model Verification of Ritonavir Simulated PK profile
Supplemental Figure 3 - PBPK Model Verification of Dasabuvir Simulated PK profile