Data Supplement
Files in this Data Supplement:
- Supplemental Data -
A physiologically based pharmacokinetics model for bosentan
Supplemental Table 1 - Values for physiological parameters
Supplemental Table 2 - The list of parameters with fixed values in victim model
Supplemental Figure 1 - Observed (Marker) and fitted (solid line) human plasma free fraction (A) and blood to plasma ratio (B)
Supplemental Figure 2 - Observed (markers) and simulated (solid lines) induction effect of CYP3A4 (A and C) and 2B6 (B and D) due to bosentan
Reference