Data Supplement
- Supplemental Data -
Supplemental Tables 1 - 40
Supplementary Figure 1 - Structure of a general PBPK model used to describe the kinetics of metformin (center) and associated nested permeabilitylimited liver (Perf, left) and mechanistic kidney (Mech KiM, right) models
Supplementary Figure 2 - Effect of Renal Impairment (RI) and Inhibition on the Renal Clearance of Metformin in Males
Supplementary Figure 3 - Effect of Renal Impairment (RI) and Fraction Unbound on the Renal Clearance of Metformin with Accompanying Inhibition of OCT2
Supplementary Figure 4 - Effect of Renal Impairment (RI) and Fraction Unbound on the Renal Clearance of Metformin with Accompanying Inhibition of MATE1
Supplementary Figure 5 - Impact of Renal Impairment (RI) on the Dose Dependency of Metformin in Females
Supplementary Figure 6 - Impact of Renal Impairment (RI) and Drug Transporter Expression on the Renal Clearance of Metformin
Supplementary Figure 7 - Effect of Renal Impairment (RI) and Inhibition on the Renal Clearance of Metformin in Females
Supplementary Figure 8 - Effect of Changes in Renal Impairment (RI) and Fraction Unbound on the Renal Clearance of Metformin with Varying Expression of OCT2 and MATE1 in Females