Data Supplement
- Supplemental Data -
Supplemental Table 1 - Validation of Kinetics Model by Comparison of Simulated versus Observed Microsomal Kinetic Parameters.
Supplemental Table 2 - Effect of Microsome Incubation Media on Microsomal CLint 4OHCP formation kinetic parameters were estimated in 0.1 M phosphate buffer (used in the enzyme assays) and Ham’s F12 media (used in the cell-based assays) and CLint in the two conditions were compared by virtue of a ratio.
Supplemental Table 3 - Comparison of CYP2B ortholog homology.
Supplemental Table 4 - Calculated average relative densities of immunoblot-detected CYP2B orthologs.
Supplemental Figure 1 - Linear transformations of microsomal kinetics data.
Supplemental Figure 2 - Analysis of Simulated Kinetics.
Supplemental Figure 3 - Verification of protein loading for western blots.
Supplemental Figure 4 - Mouse PK data for model comparison.