Data Supplement
- Supplemental Data -
Supplemental Table 1- LC-MS/MS conditions for in vitro uptake and Kp experiments
Supplemental Table 2 - LC-MS/MS conditions for protein binding and in vivo studies
Supplemental Table 3 - Data sources for physiological parameters in dogs
Supplemental Table 4 - In vivo and in vitro clearance data in rats
Supplemental Table 5 - Individual uptake parameters obtained in the three lots of plated dog hepatocytes
Supplemental Figure 1 - Cell-to-medium concentration ratio (Kp)-time profiles of 9 OATP substrates in three lots of plated dog hepatocytes
Supplemental Table 6 - Individual Kp, Kpuu and fu,cell parameters obtained in three lots of plated dog hepatocytes
Supplemental Table 7 - Comparison of estimated CLactive, CLpassive and fucell of rosuvastatin from short and long
incubation periods in plated dog hepatocytes (lot XVD)Supplemental Figure 2 - Two compartment mechanistic modelling of rosuvastatin concentration-time profile
Supplemental Table 8 - In vivo and in vitro clearance data in cynomolgus monkeys
Supplemental Table 9 - In vivo and in vitro clearance data in humans
Supplemental Figure 3 - Correlation of CLpassive and fucell values with physicochemical properties logD7.4 and relationship between fucell and fup
References