Data Supplement
- Supplemental Figures -
Supplementary Figure 1 - NMR spectrum of atipamezole.
Supplementary Figure 2 - Comparative TICs of atipamezole and its metabolites obtained from rat and human liver microsomes before and after incubation with NADPH.
Supplementary Figure 3 - Comparative TICs of atipamezole and its metabolites obtained from rat and human liver microsomes before and after incubation with UDPGA.
Supplementary Figure 4 - Comparative TICs of atipamezole and its metabolites obtained from bile of BDC rat before and after administration of atipamezole.
Supplementary Figure 5 - MS /MS spectra of oxidized metabolites of atipamezole.
Supplementary Figure 6 - MS /MS spectra of UGT-conjugated metabolite of atipamezole in HLM.